Trastornos renales e hidroelectrolíticos
C a p í t u l o 4 Fisiopatología y tratamiento de los trastornos acidobásicos respiratorios y mixtos 135
Tabla 4–5 Ejemplo de un trastorno acidobásico triple Acontecimiento clínico Vómitos → Shock hipovolémico →
Hiperventilación
↓
↓
↓
Trastorno acidobásico
Alcalosis metabólica
Acidosis metabólica
Alcalosis
+
+
respiratoria
pH
7.53
7.35
7.46
(mmHg)
44 36 12
30 16 30
20 14 32
PaCO 2 [HCO 3
− ] (mmol/L)
Desequilibrio aniónico (mEq/L)
b i b l i o g r a f í a 1. BevenseeMO,BoronWF.Control of intracellular pH.In: Alpern RJ,Hebert SC,eds. Seldin and Giebisch’s the Kidney: Physiology and Pathophysiology .4th ed.Amsterdam,The Netherlands: Elsevier; 2008:1429–1480. 2. Sapir DG,Levine DF,SchwartzWB.The effects of chronic hypoxemia on electrolyte and acid-base equilibrium: an examination of normocapneic hypoxemia and of the influence of hypoxemia on the adaptation to chronic hypercapnia. J Clin Invest . 1967;46:369–377. 3. Adrogue HJ,Gennari FJ,Galla,JH,et al.Assessing acid-base disorders. Kidney Int . 2009;76:1239–1247. 4. Weinberger SE,Schwarzstein RM,Weiss JW.Hypercapnia. N Engl J Med . 1989;321:1223–1231. 5. Askanazi J,Nordenstrom J,RosenbaumSH,et al.Nutrition for the patient with respiratory failure. Glucose vs. fat. Anesthesiology . 1981;54:373–377. 6. Giebisch G,Berger L,Pitts RF.The extrarenal responses to acute acid-base disturbances of respiratory origin. J Clin Invest . 1955;34:231–245. 7. Krapf R. Mechanisms of adaptation to chronic respira- tory acidosis in the rabbit proximal tubule. J Clin Invest . 1989;83:890–896. 8. Ruiz OS, Arruda JAL, Talor Z. Na-HCO 3 cotransport and Na-H antiporter in chronic respiratory acidosis and alkalosis. Am J Physiol . 1989;256:F414–F420. 9. Krapf R. Mechanisms of adaptation to chronic respira- tory acidosis in the rabbit proximal tubule. J Clin Invest . 1989;83:890–896. 10. Verlander JW, Madsen KM, Tischer CC. Effect of acute respi- ratory acidosis on two populations of intercalated cells in rat collecting duct. Am J Physiol .1987;253:F1142–F1156. 11. Schwartz WB, Brackett NC Jr, Cohen JJ. The response of extracellular hydrogen ion concentration to graded degrees of chronic hypercapnia: the physiologic limitation of the defense of pH. J Clin Invest . 1965;44:291–301. 12. Brackett NC Jr,Cohen JJ,SchwartzWB.Carbon dioxide titration curve of normal man: effect of increasing degrees of acute hypercapnia on acid-base equilibrium. N Engl J Med . 1965;272:6–12. 13. Brian JE Jr.Carbon dioxide and the cerebral circulation. Anesthesiology . 1998;88:1365–1386. 14. Pollock JM,DeiblerAR,WhitlowCT,et al.Hypercapnia-induced cerebral hyperperfusion: an underrecognized clinical entity. Am J Neuroradiol . 2009;30:378–385. 15. Dulfano MJ, Ishikawa S. Hypercapnia: mental changes and extrapulmonary complications.An expanded concept of the “CO 2 intoxication” syndrome. Ann Intern Med . 1965;63:829–841. 16. Epstein FH.Signs and symptoms of electrolyte disorders. In: Maxwell MH,Kleeman CR,eds. Clinical Disorders of
Fluid and Electrolyte Metabolism .3rd ed.NewYork,NY: McGraw-Hill; 1980:499–516. 17. Potkin RT,Swenson ER.Resuscitation from severe acute hypercapnia: determination of limits of tolerance and survival. Chest . 1992;102:1742–1745. 18. Chabot F, Mertes PM, Delorme N, et al. Effect of acute hypercapnia on alpha atrial natriuretic peptide, renin, angiotensin II, aldosterone, and vasopressin plasma levels in patients with COPD. Chest . 1995;107: 780–786. 19. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med . 2000;342:1301–1308. 20. Lakshminarayan S,Sahn SA,Petty TL.Bicarbonate therapy in severe acute respiratory acidosis. Scand J Respir Dis . 1973;54:128–131. 21. Bulger RJ, Schrier RW,ArendWP, et al. Spinal-fluid ac- idosis and the diagnosis of pulmonary encephalopathy. N Engl J Med . 1966;274:433–437. 22. Brackett NC Jr, Wingo CF, Muren O, et al. Acid-base response to chronic hypercapnia in man. N Engl J Med . 1969;280:124–130. 23. VanYpersele de Strihou C,Brasseur L,DeConinck J.The “carbon dioxide response curve”for chronic hypercapnia in man. N Engl J Med . 1966;275:117–122. 24. Manfredi F, Merwarth CR, Buckley CE III, et al. Pap- illedema in chronic respiratory acidosis. Am J Med . 1961;30:175–180. 25. Miller A, Bader RA, Bader ME. The neurological syn- drome due to marked hypercapnia, with papilledema. Am J Med . 1962;33:309–318. 26. Bushinsky DA. The contribution of acidosis to renal osteodystrophy. Kidney Int . 1995;47:1816–1832. 27. Bushinsky DA. Stimulated osteoclastic and suppressed osteoblastic activity in metabolic but not respiratory acidosis. Am J Physiol . 1995;268:C80–C88. 28. Bushinsky DA, ParkerWR,Alexander KM, et al. Meta- bolic,but not respiratory,acidosis increases bone PGE2 levels and calcium release. Am J Physiol Renal Physiol . 2001;281:F1058–F1066. 29. Piper AJ, Grunstein RR. Obesity hypoventilation syn- drome: mechanisms andmanagement. Am J Respir Crit Care Med . 2011;183:292–298. 30. Nowbar S,Burkart KM,Gonzales R,et al.Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med . 2004;116:1–7. 31. Neff TA, Petty TL. Tolerance and survival in severe chronic hypercapnia. Arch InternMed .1972;129:591–596.
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