McKenna's Pharmacology for Nursing, 2e

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C H A P T E R 4 8 Drugs affecting blood coagulation

4. The low-molecular-weight heparin of choice for preventing deep venous thrombosis after hip replacement therapy is: a. tinzaparin. b. dalteparin. c. heparin. d. enoxaparin. 5. A thrombolytic agent could be safely used in: a. CVA within the last 2 months. b. acute MI within the last 3 hours. c. recent, serious GI bleeding. d. caesarean birth. 6. Antihaemophilic agents are used to replace missing clotting factors to prevent severe blood loss. The most common side effect or side effects associated with the use of these drugs are: a. bleeding. MULTIPLE RESPONSE Select all that apply. 1. Hageman factor is known to activate which of the following? a. the clotting cascade b. the anticlotting process c. the inflammatory response d. platelet aggregation b. dark stools and urine. c. hepatitis and AIDS. d. constipation.

2. Plasminogen is converted to plasmin, a clot- dissolving substance, by which of the following? a. nicotine b. Hageman factor c. streptokinase

d. pyrogens e. thrombin f. Christmas factor

3. Antiplatelet drugs block the aggregation of platelets and keep vessels open. These drugs would be useful in which of the following? a. maintaining the patency of grafts b. decreasing the risk of fatal MI c. preventing reinfarction after MI d. dissolving a pulmonary embolus and improving oxygenation e. decreasing damage in a subarachnoid bleed f. preventing thromboembolic strokes 4. Evaluating a person who is taking an anticoagulant for blood loss would usually include assessing for which of the following? a. the presence of petechiae b. bleeding gums while brushing the teeth c. dark-coloured urine

d. yellow colour to the sclera or skin e. the presence of ecchymotic areas f. loss of hair

e. thromboxane A 2 f. troponin coupling