McKenna's Pharmacology for Nursing, 2e

991

Index

Pilocarpine, 488–490, 958 Pimecrolimus, 263, 264 Pindolol, 477, 478, 676 Pineal gland, 514 Pinocytosis, 72, 75 Pinworm infections, 180 pinworms, 179 Pioglitazone, 587, 588, 589

Povidone-iodine, 950 Pralidoxime, 491, 492 Pramipexole, 374–376 Prasugrel, 756, 758

Primidone, 357, 358–359, 362 Prinzmetal angina, 713, 715 Proarrhythmic, 696, 701 Procaine penicillin, 108, 109 Procarbazine, 195, 197 Prochlorperazine, 200, 335, 336, 337, 929, 931, 932, 934 Progesterone, 596, 597–600, 607, 609, 612–614, 619 effects, 599 Progestogens, 606, 607–608, 610, 613–614 adverse effects, 613 contraindications and cautions, 613 drug–drug interactions, 613 pharmacokinetics, 610 Promethazine, 313, 853, 854, 931, 932 Propafenone, 702, 703 Propamidine isethionate, 958 Propantheline, 502, 503 Prophylaxis, 81, 86 Propionic acids, 240, 246, 247 Propofol, 354, 417, 420, 421 Propranolol, 469, 471, 477–479, 676, 696, 698, 701, 703–705, 716, 722 Propylthiouracil, 552, 554, 557, 560, 561 Prostaglandins, 606, 620, 622–624, 896, 901, 910–912 adverse effects, 622, 911 care considerations, 623–624, 911–912 contraindications and cautions, 622, 910–911 pharmacokinetics, 622, 910 therapeutic actions and indications, 622, 910 Prostate gland, 800 Protamine sulfate, 757, 766 Protease inhibitors, 126, 136, 139–140 adverse effects, 140 contraindications and cautions, 139–140 drug–drug interactions, 140 pharmacokinetics, 139 therapeutic actions and indications, 139 Proteasome inhibitors, 220–222 adverse effects, 221 contraindications and cautions, 221 drug–drug interactions, 222 pharmacokinetics, 221 therapeutic actions and indications, 220–221 Protein binding, 22 Proton pump inhibitors, 896, 900, 906–908 adverse effects, 898, 907 care considerations, 907–908 contraindications and cautions, 907 drug–drug interactions, 907 interstitial nephritis, 908 pharmacokinetics, 907 therapeutic actions and indications, 906–907 Protozoa, 163, 164 Protozoal infections, 164, 170–172

Pravastatin, 738, 740–741 Praziquantel, 183, 185, 186 Prazosin, 471, 475, 483, 676 Preclinical trials, 2, 6 Prednisolone, 539, 542, 543 Prednisone, 356, 539, 542–544, 545–547

Piperacillin, 109 Piroxicam, 247 Pituitary agents. See Hypothalamic and pituitary agents Pituitary gland, 513, 515, 516 anterior pituitary, 512, 515, 516 intermediate lobe, 515, 516 posterior pituitary, 512, 515, 516 Placebo effect, 16, 27, 46 Placenta and breast milk, 23 hormones and, 514 Plague, 282 Plants, 3–4, 5 Plasma, 774, 775 Plasma esterase, 416, 426 Plasminogen, 750, 754 Plasmodium , 163, 164–166 Platelet aggregation, 750, 751, 752 Platyhelminths (flatworms), 179, 181 Pneumococcal vaccine, 274, 279 Pneumocystis carinii pneumonia, 163, 172 Pneumonia, 834, 838 Pneumothorax, 834, 838

Pregabalin, 354, 365–368 Pregnancy, 8–9, 600–601 adrenergic agonists, 456

adrenergic blocking agents, 471 anaemias, drugs used to treat, 779 anthelmintic agents, 183 antianginal agents, 717 antiarrhythmic agents, 701 antibiotics, 93 anticholinergic agents, 502 antidepressant agents, 318 antiemetic agents, 931 antifungal agents, 151 anti-infective agents, 82 anti-inflammatory agents, 241 antimigraine agents, 410 antineoplastic agents, 194 antiparkinsonism agents, 375 antiprotozoal agents, 164 antiseizure agents, 354 antiviral agents, 128 anxiolytic and hypnotic agents, 304 blood pressure, drugs affecting, 667 cardiotonic agents, 686 cholinergic agonists, 489 classification of drugs, 9 coagulation, drugs affecting, 752 corticosteroids, 540 diuretic agents, 807 female reproductive system, drugs affecting, 608 gastrointestinal secretions, drugs affecting, 899 hypoglycaemic agents, 574 hypothalamic and pituitary agents, 523 immune modulators, 260 laxatives and antidiarrhoeal agents, 917 lipid-lowering agents, 736 lower respiratory tract agents, 866 male reproductive system, drugs affecting, 629 muscle relaxants, 386 neuromuscular junction (NMJ) blocking agents, 435 opioids, 401 psychotherapeutic agents, 335

Podophyllotoxin, 952 Podophyllum resin, 952 Poisoning, 31, 36 Poisons uniform scheduling, 9, 10 Poliomyelitis vaccine, 280 Polycystic ovary syndrome hypoglycaemic drugs, 589 Polydipsia, 572, 575–576 Polyphagia, 573, 575 Poractant, 881 Posaconazole, 151–154

Positive inotropic effect, 681, 683 Posterior pituitary, 512, 515, 516 hormones, drugs affecting, 521, 530–533 adverse effects, 533 care considerations, 533 contraindications and cautions, 532–533 drug–drug interactions, 533 pharmacokinetics, 532 therapeutic actions and indications, 530 Post-marketing surveillance, 2, 8 Postmenopausal osteoporosis, 551, 563, 564 Postoperative nausea and vomiting, 933–934 Potassium channel openers, 714, 716, 825–726 Potassium regulation, 798 potassium-rich foods, 814 Potassium-sparing diuretics, 658, 803, 806, 813–814

thyroid and parathyroid agents, 554 upper respiratory tract agents, 844 urinary tract agents, 820 Premature atrial contractions (PACs), 696, 699 Premature ventricular contractions (PVCs), 696, 699, 700 Pre-medication, 416, 418

Prilocaine, 425, 426 Primaquine, 166–168

agents for, 172–174 adverse effects, 173