MW_Nefrología de _1ed

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Capítulo 20 • Trasplante incompatible por ABO o HLA e intercambio de donantes

Donante y receptor en el par incompatible original (debido a incompatibilidad por ABO o HLA)

Pareja de donante y receptor en el intercambio de donantes de riñón pareados: ya no incompatibles debido al intercambio

Receptor A

Donante A

Receptor A

Donante A

X

Donante B

Receptor B

X

Donante B

Receptor B

Donante C

Receptor C

Donante C

Receptor C

X

Donante D

X

Receptor D

Receptor D

Donante D

Figura 20-2. Ilustración del intercambio de donantes de riñón pareados.

REFERENCIAS 1. Denomme GA. The structure and function of the molecules that carry human red blood cell and platelet antigens. Transfus Med Rev . 2004;18(3):203-31. 2. American Red Cross. 2023. Accessed April 8, 2023 https://www.redcrossblood.org/donate blood/blood-types.html 3. de Weerd AE, Betjes MGH. ABO-incompatible kidney transplant outcomes. A meta- analysis. CJASN . 2018;13(8):1234-43. 4. Montgomery RA, Locke JE, King KE, et al. ABO incompatible renal transplantation: a paradigm ready for broad implementation. Transplantation . 2009;87(8):1246-55. 5. Shirakawa H, Ishida H, Shimizu T, et al. The low dose of rituximab in ABO-incompatible kidney transplantation without a splenectomy: a single-center experience. Clin Transplant . 2011;25(6):878-84. 6. Sonnenday CJ, Warren DS, Cooper M, et al. Plasmapheresis, CMV hyperimmune globulin, and anti-CD20 allow ABO-incompatible renal transplantation without splenectomy. Am J Transplant . 2004;4(8):1315-22. 7. Bryan CF, Nelson PW, Shield CF, et al. Long-term survival of kidneys transplanted from live A2 donors to O and B recipients. Am J Transplant . 2007;7(5):1181-4. 8. Williams WW, Cherikh WS, Young CJ, et al. First report on the OPTN National variance: allocation of A2/A2 B deceased donor kidneys to blood group B increases minority trans plantation. Am J Transplant . 2015;15(12):3134-42. 9. Haas M, Rahman MH, Racusen LC, et al. C4d and C3d staining in biopsies of ABO- and HLA-incompatible renal allografts: correlation with histologic findings. Am J Transplant . 2006;6(8):1829-40. 10. Haas M, Segev DL, Racusen LC, et al. C4d deposition without rejection correlates with reduced early scarring in ABO-incompatible renal allografts. JASN (J Am Soc Nephrol) . 2009;20(1):197-204.

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