Kaplan + Sadock's Synopsis of Psychiatry, 11e

A naturally occurring molecule made from the amino acid methionine and ATP, serves

as a methyl donor in human cellular metabolism.

None Comments

None

Flowers are poisonous.

Polygala Polygala is a genus of about 500 species of flowering Table 29.34-3 Phytomedicinals with Psychoactive Effects ( continued ) Name Ingredients Use Adverse Effects a Interactions Dosage a plants belonging to the family Polygalaceae, commonly known as milkwort or snakeroot. Used for insomnia, forgetfulness, mental confusion, palpitation, seizures, anxiety, and listlessness. Contraindicated in patients who have ulcers or gastritis, should not be used long term. None Dosage of polygala is 1.5–3 g of dried root, 1.5–3 g of a fluid extract, or 2.5–7.5 g of a tincture. A polygala tea can also be made, with a

maximum of

three cups per day.

None Exact dosage unknown

400–1,600 mg/ day

triterpenes, cucurbitacins, caffeic acids Antidepressant Overdose or long-term doses may lead to gastroenteritis and nephritis Undetermined 1.8 g of powder four times a day

SNRIs may result in serotonin

syndrome. Interacts with levodopa, meperidine,

pentazocine, and tramadol.

Use with SSRIs or

movements,

bloating, nausea, and abdominal cramps.

GI symptoms, anxiety, nightmares, insomnia, and worsening of Parkinson’s symptoms.

Loose bowel

Rehmannia Iridoid glycosides Stimulates the release of cortisol. Used in lupus, rheumatoid arthritis

(RA), fibromyalgia, and

multiple sclerosis. May improve asthma and

urticaria. Used to treat menopause, hair loss, and impotence.

Used for arthritis and fibromyalgia, may be effective as an

augmentation strategy

for SSRI in depression.

S-adenosyl- l -

Rhodiola rosea Potentiator, monoterpene alcohols,

flavonoids

methionine

Flavonoids,

S-adenosyl- l -

methionine (SAMe)

L. Anagallis arvensis

Scarlet Pimpernel,

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