Kaplan + Sadock's Synopsis of Psychiatry, 11e

( continued )

First degree (pooled) 9% a 5%–20% b , c , e 9% a 18% a 1%–10% b , c , d 17%–25% a , p 15%– 25% a , n 20% a 27% a 5% a 12%– 31% a 5%–10% a 15%–60% q 5%– 5%–

Siblings 9%–16% d , i , j , k 5%– 20% b , c , e , h , i 30% b , c , h , i — 25%–35% l — — — — — — 17%–25% g Parent 5%–13% g , i , j , k , o 15% c , d , e , h , m 7%– 19% h , i 7%– 19% h , i 30% b , c , h , i

Disorder Nervosa ADHD Men Women Men Women 1%– 15% b , c 2%– 23% b , c 0.5%– < 1% b , c , d 1.5%–3% a , p 1.5%– 3.5% a , n 3.5% a 14% a 3% a 4%–11% a 0.1% a 3%–5% f Disorder Phobia

2%–6% h , i 5% h — — — — — — — — — — 3%–9% q

depression, bipolar

disorder,

oppositional disorder, conduct

disorder,

anxiety

disorders

Grandparent 2%–8% i , j — — — — — — — — — — — — Unipolar Tourette’s — Unipolar major — — — Unipolar

— 25%–35% l — — — — — — —

Both parents 45% h , i 50%–75% for affective disorder b , d , h , i — — — — — — — — — — — Second degree (pooled)

Uncle/aunt 1%–4% i , j — — — — — — — — — — — — Nephew/ niece

2%–4% i , j , o — — — — — — — — — — — —

Half-sibling 4% i , j — — — — — — — — — — — — disorder, disorder chronic tics,

First cousin 2%–6% i , j — — — — — — — — — — — — Risks for additional mental disorders Spectrum disorders (schizoaffective disorder, schizotypal personality disorder, dependence, disorders, bipolar disorder, unipolar unipolar depression

Third degree — — — — — — — — — — — — — substance Schizophrenia, other psychotic depression

Anorexia

Alcohol

Dependence

Generalized Anxiety

Panic

Obsessive-

Compulsive Disorder

disorder ∼ 30%

depression, FDR; RR

mood or

psychotic

Schizoaffective Disorder

Unipolar Major

Depressive Disorder

Anxiety disorders, alcohol dependence, dysthymia, ADHD

Affected relative General population 1% a 0.8%– 1.6% b , c , d , e

∼ 20%–30%

schizoaffective disorder,

cyclothymia, anxiety disorder,

FDR; RR

any affective disorder:

Table 28.14-6 Empirical Risks for Selected Mental Disorders Schizophrenia Bipolar Disorder

paranoid

personality

disorder);

unipolar

and major

depression

905