The COVID-19 Textbook

F γ Rn

ADCC, antibody-dependent cellular cytotoxicity; ADCP, antibody-dependent cellular phagocytosis; CDC, complement-dependent cytotoxicity; DC, dendritic cell; Ig, immunoglobulin. From Gillis C, Gouel-Cheron A, Jonsson F, Bruhns P. Contribution of human Fc γ Rs to disease with evidence from human polymorphisms and transgenic animal studies. Front Immunol . 2014;5:254. 251

Recycling, transport, Ag uptake

Major role Activation Activation Inhibition Activation Activation Decoy; activation IgG recycling; transport Major expression Monocytes/mac B cells, DCs, NK cells, mono NK cells, monocytes/ Monocytes/

macrophages,

neutrophils, DCs,

endothelium, and

syncytiotrophoblasts

Fc γ RIIIB

Neutrophils. Induc ible expression in basophils

ADCC/ADCP, CDC, degranulation

CD CD64 CD32A CD32B CD32C CD16A CD16B

F γ RIIIA

macrophages

ADCC/ADCP, CDC, degranulation

Fc γ RIIC

Antigen presenta

tion, ADCC, ADCP

cytes/macrophages, neutrophils

Fc γ RIIB

Antigen presenta

tion, ADCC, ADCP

basophils. induc ible expression in neutrophils

and monocytes/ macrophages

Fc γ RIIA

Antigen presenta

tion, ADCC, ADCP

Monocytes/macro

phages, neutrophils, DCs, basophils,

eosinophils and mast cells

Fc γ RI

Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. rophages and in ducible expression in neutrophils and mast cells CDC, phagocytosis, opsonization

TABLE 8.2 Summary of IgG Fc-receptors in humans Name

Main

functions