The COVID-19 Textbook

V(D)J recombination Somatic hypermutation ( )

D 2 D 1 V n V 3 V 2 V 1

V

FR2 FR1

FR2 FR1

FR3

FR4 FR3 CDR3 CDR2 CDR1

C C J n J 2 J 1 D n Immunoglobulin heavy chain

CDR3 CDR2 CDR1

J D

FR4

C

site

Light chain

FcRn binding site

Complement binding

Heavy chain

Fc Glycosylation

Disulfide bridges

CH2

CH3

Fv

~25 kDa

CH1

FIGURE 8.1 The structure of an antibody . The inset shows the CDR loops and framework (FR) of the variable region. CDR, complementarity determining region. 249

VH

CL

Fc

Hinge

region

~50 kDa

VL

Fab

~50 kDa

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