The COVID-19 Textbook

Contents

Preface v Acknowledgments vii Contributors ix

Section 1: Introduction

1

1

Epidemiology of COVID-19

3

Sten H. Vermund • Mahima Kaur

2

Molecular Biology of SARS-CoV-2

45

Roberto Patarca • William A. Haseltine

Section 2: Virology

115

3

Bat Coronaviruses

117

Chee Wah Tan • Feng Zhu • Akshamal Gamage • Lin-Fa Wang

4 Structure and Function of SARS-CoV-2 Spike Protein

136

Bing Chen • Jeremy Luban

5

SARS-CoV-2 Variants Jacob E. Lemieux • Jeremy Luban

156

Section 3: Immunology

173

6 Genetic Determinants of Susceptibility and Resistance to SARS-CoV-2

175

Maureen P. Martin • Mary Carrington

Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. 7 Evasion of Innate Host Defenses by SARS-CoV-2 and Its Pathogenetic Correlates 214

Roberto Patarca • William A. Haseltine

xiii