Rosen's Breast Pathology, 4e

369

Ductal Carcinoma In Situ

A

B

FIG. 11.50.  Coexistent intraductal and in situ lobular carcinoma in a single duct-lobular unit. A,B: DCIS, apo- crine type, is present in adenosis on the right . LCIS fills expanded lobular glands on the left . Apocrine DCIS is sur- rounded by LCIS in the upper left area . Calcifications are present in the ductal and lobular in situ carcinoma. Apo- crine DCIS ( right ) associated with LCIS ( left ). C: DCIS cells ( right ) are immunoreactive for E-cadherin, and LCIS cells ( left ) are not.

C

FIG. 11.51.  DCIS, high grade. A: Solid (“comedo”) carci- noma. Note mitotic activity. B: Papillary carcinoma with necrosis. C: Clear cell carcinoma.

C