Rosen's Breast Pathology, 4e

351

Ductal Carcinoma In Situ

A

B

D

C

FIG. 11.21.  DCIS, cribriform. A: Minimal microlumen formation, some with calcifications. Nuclei are of low grade. B: Relatively round microlumina in the distended duct with low-to intermediate-grade nuclei. C: Central and peripheral microlumina with central necrosis and calcifications. D: Microlu- mina with irregular contours. There is central necrosis with calcification.

FIG. 11.22.  DCIS, cribriform. A: Peripheral microlumina, some of which are slit shaped, and a prom- inent central lumen with degenerating cells and calcification. B: Magnified view showing degen- erating tumor cells in the lumen. C: Another duct from the same specimen with a conventional cribriform structure. D: DCIS with conventional cribriform structure. The duct is filled with histio- cytes and calcifications.