Rosen's Breast Pathology, 4e

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Chapter 33

E

F

FIG. 33.5.  Fibroadenoma, infiltrating ductal carcinoma. A: IDC involving the periphery of a sclerotic fibroadenoma. Intraductal carcinoma is shown on the left . B-D: Cribriform intraductal carcinoma with calcifications in a myxoid fibroadenoma from a 30-year-old woman. Non- carcinomatous epithelium is on the left and invasive carcinoma is on the far right (B). Several ducts with cribriform intraductal carcinoma and calcifications in the midst of invasive well-­ differentiated ductal carcinoma (c). Immunoreactivity for smooth muscle myosin heavy chains is shown around intraductal carcinoma. Staining is absent around invasive carcinoma (D). E: IDC secondarily extending into a sclerosed fibroadenoma. F: Another ductal carcinoma invad- ing circumscribed pseudoangiomatous stromal hyperplasia. The tumor cells appear to occupy the “pseudoangiomatous” spaces ( upper right ).