Rosen's Breast Pathology, 4e

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Preface

pathologic phenotypic classification presented in this book. It is possible that the pathology report for a mammary carci- noma in the coming decade will include a secondary classifi- cation based on molecular markers. Ultimately, it is genotype that serves as the basis for phenotype, and the complex, long- term process of unraveling this relationship will benefit from the work of investigators familiar with both aspects of mam- mary disease. Surgical pathologists are uniquely qualified to fill this role and to assimilate these advances into routine diagnostic testing for the benefit of patients. In addition to the extensive revisions and editing of individual chapters by the authors, this book has been

subjected to rigorous scrutiny by the publisher’s excellent staff throughout the production process. The choice of il- lustrations, the references listed, the selection of data cited, and the conclusions expressed reflect the experience and opinions of the editors and authors. I had the extraordi- nary opportunity to read all of the new references as well as to review and edit the manuscripts and pictures of each chapter. I have also substantially revised and updated the Introduction.

Paul P. Rosen, MD

List of Abbreviations A list of the most frequently used abbreviations in this book can be found on page 1351. LEGENDS FOR COVER IMAGES Front Cover Image Legends (clockwise from top left): radial sclerosing lesion with ductal hyperplasia, cribriform DCIS (E-cadherin positive) and LCIS (E-cadherin negative) in a duct, secretory carcinoma, and fluorescence in situ hybrid- ization (FISH) in secretory carcinoma with separated red and green signals indicating a disrupted NTRK3 gene. (Courtesy of Dr. A. John Iafrate and Ms. Clarice Bo-Moon Chang.) Back Cover Image Legends (clockwise from top left): partially infarcted adenomyoepithelioma; metaplastic carcinoma, spindle and squamous type; reaction to contents of a ruptured breast implant; solid papillary carcinoma (arrows indicate fibrovascular cores).