Non-Neoplastic Dermatopathology

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5 Disorders of the Subcutis

Pancreatic Panniculitis

Alpha-1 Antitrypsin Deficiency Panniculitis

Prognosis

Dependent upon associated pancreatic disease. Panniculitis usually resolves with clearing of pancreatic inflammation in cases associated with pancreatitis. Individuals with pancreatic carcinoma have a more prolonged course and high mortality rate. The triad of pancreatitis, arthralgias, and peripheral eosinophilia is associated with a poor prognosis.

Untreated, severe cases can lead to death. Resolution of disease is typically seen with adequate treatment, although relapses may occur.

Figure 5.10.1 Pancreatic panniculitis. Dense deep dermal and lobular subcutaneous inflammatory infiltrate with reactive vascular proliferation and hemorrhage. Note area of fat necrosis at lower left corner of image.

Figure 5.10.2 Pancreatic panniculitis. Lobular infiltrate predominated by neutrophils. Necrosis with focal calcification (arrow).

Figure 5.10.3 Pancreatic panniculitis. Coagulative necrosis and saponification of fat lobules with peripheral rim of neutrophilic inflammation. Figure 5.10.4 Alpha-1 antitrypsin deficiency panniculitis. Inflammation of subcutaneous septae and fat lobule (arrow). Note relatively uninvolved fat lobule at lower left. Copyright © Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. 2023