Non-Neoplastic Dermatopathology

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5 Disorders of the Subcutis

Figure 5.3.1 Erythema nodosum. Fibrosis and thickening of subcutaneous septae with dense mixed infiltrate that extends minimally into the periphery of the fat lobules.

Figure 5.3.2 Erythema nodosum. Thickened septae with mixed infiltrate predominated by lymphocytes and histiocytes with few eosinophils. Multinucleate giant cells are conspicuous.

Figure 5.3.3 Erythema nodosum. Miescher radial granulomas formed by multinucleate giant cells surrounding irregular cleft-like spaces.

Figure 5.3.4 Traumatic panniculitis. Hyalinized fibrosis forms capsule around area of fat necrosis with calcification.

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Figure 5.3.5 Traumatic panniculitis. Fat necrosis with formation of fat microcysts of varying size. Foamy histiocytes surround the fat cells and microcysts (lipophagic fat necrosis). No discrete granuloma formation.

Figure 5.3.6 Traumatic panniculitis. Lipomembranous change characterized by feathery eosinophilic material at the periphery of cystic spaces. There is a peripheral hyalinized fibrotic capsule (lower right) and prominent calcification (upper left).