Non-Neoplastic Dermatopathology

249

5.2 Erythema Nodosum vs Behcet Disease

Figure 5.2.1 Erythema nodosum. Thickening of subcutaneous septae with inflammation that extends minimally into the periphery of fat lobules. The lobules are generally preserved.

Figure 5.2.2 Erythema nodosum. Septal fibrosis with reactive vascular proliferation and mixed inflammatory infiltrate. Multinucleate histiocytes are conspicuous. Vessels show reactive change but there is no vasculitis.

Figure 5.2.3 Erythema nodosum. Fibrosis of septa with mixed infiltrate including eosinophils, lymphocytes, histiocytes, and multinucleate giant cells. Neutrophils present but do not predominate.

Figure 5.2.4 Erythema nodosum. Miescher radial granulomas characterized by macrophages surrounding cleft-like spaces with few neutrophils.

Copyright © Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. 2023

SUBCUTIS

5 DISORDERS OF THE

Figure 5.2.5 Behcet disease. Predominately lobular inflammatory infiltrate with mild edema of septae.

Figure 5.2.6 Behcet disease. Mixed lobular infiltrate with septal edema and mild inflammation.