Mukherjee_Interventional Cardiology Board Review, 4e

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7 Antiarrhythmics, Inotropes, Sedatives, and Lipid-Lowering Agents

7.29 A patient is mechanically ventilated and receiv ing fentanyl and midazolam for analgesia and sedation. Respiratory function has improved, and ventilator settings are minimal in preparation for extubation. However, the patient has a positive Confusion Assessment Method for the ICU (CAM ICU) score and becomes agitated when sedation is decreased. The ongoing agitation is preventing liberation from the ventilator. Which strategy is best to facilitate extubation? A. Start haloperidol B. Change midazolam to dexmedetomidine C. Start quetiapine D. Discontinue fentanyl

7.30 Which statement regarding the interaction be tween morphine and oral P2Y12 inhibitors is TRUE? A. Morphine may delay absorption of clopido grel and prolong the duration of residual platelet reactivity B. Morphine increases the risk of cardiovascu lar mortality in patients with an ACS C. Morphine delays onset of antiplatelet activity after clopidogrel administration via CYP2C19 inhibition D. Morphine does not affect the onset of anti platelet activity after ticagrelor or prasugrel administration

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