McKenna's Pharmacology for Nursing, 2e

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P A R T 1 1  Drugs acting on the gastrointestinal system

the stomach acid without increasing acid production is a clinical challenge. ■■ The GI protectant sucralfate forms a protective coating over the eroded stomach lining to protect it from acid and digestive enzymes to aid healing. ■■ The prostaglandin misoprostol blocks gastric acid secretion while increasing the production of bicarbonate and mucus lining in the stomach. ■■ Digestive enzymes such as pancreatic enzymes may be needed if normal enzyme levels are very low and proper digestion cannot take place. Knowing your strengths and weaknesses helps you to study more effectively. Take a PrepU Practice Quiz to find out how you measure up! ONLINE RESOURCES An extensive range of additional resources to enhance teaching and learning and to facilitate understanding of this chapter may be found online at the text’s accompanying website, located on thePoint at http://thepoint.lww.com. These include Watch and Learn videos, Concepts in Action animations, journal articles, review questions, case studies, discussion topics and quizzes. BIBLIOGRAPHY Al-Sohaily, S. & Duggan, A. (2008) Long-term management of patients taking proton pump inhibitors. Australian Prescriber, 31, 5–7. Dial, S., Delaney, J. A., Barkun, A. N. & Suissa, S. (2005). Use of gastric acid suppressive agents and the risk of community acquired Clostridium difficile associated diarrhea. JAMA, 294 , 2898–2995. Farrell, M. & Dempsey, J. (2014). Smeltzer & Bare’s Textbook of Medical-Surgical Nursing (3rd edn). Sydney: Lippincott Williams & Wilkins.

Goodman, L. S., Brunton, L. L., Chabner, B. & Knollmann, B. C. (2011). Goodman and Gilman’s Pharmacological Basis of Therapeutics (12th edn). New York: McGraw-Hill. Green, C. (2010). Recommended management of GORD in general practice. Prescriber, 21(1–2) , 18–30. McKenna, L. (2012). Pharmacology Made Incredibly Easy (1st Australian and New Zealand edn). Sydney: Lippincott Williams & Wilkins. McKenna, L. & Mirkov, S. (2014). McKenna’s Drug Handbook for Nursing and Midwifery (7th edn). Sydney: Lippincott Williams & Wilkins. MEDSAFE. (2006). Proton pump inhibitors and interstitial nephritis. Prescriber Updates, 27(1) , 3. www.medsafe.govt.nz/ profs/PUarticles/watchingbriefsJune06.htm. Morcom, J. (2008). Understanding GORD from a primary nurse perspective. Gastrointestinal Nursing, 6(1) , 12–20. Pfizer New Zealand Ltd. (2005). Somac (pantoprazole) tablets data sheet. www.medsafe.govt.nz/profs/Datasheet/s/ somacHeartBurnRelieftab.pdf. Porth, C. M. (2011). Essentials of Pathophysiology: Concepts of Altered Health States (3rd edn). Philadelphia: Lippincott Williams & Wilkins. Porth, C. M. (2009). Pathophysiology: Concepts of Altered Health States (8th edn). Philadelphia: Lippincott Williams & Wilkins. Savage, R. (2001). Omeprazole-induced interstitial nephritis. Prescriber Update , 20 (Feb), 11–13. www.medsafe.govt.nz/profs/ PUarticles/omeprazole.htm. Selby, M. (2010). GORD and dyspepsia…gastrooesophageal reflux disease. Practice Nurse, 39(9) , 19–22. Simpson, I. J., Marshall, M. R., Pilmore H., et al. (2006). Proton pump inhibitors and acute interstitial nephritis—report and analysis of 15 cases. Nephrology, 11(5) , 381–385. Wileman, S. M., McCann, S., Grant, A. M., Krukowski, Z. H. & Bruce, J. (2010). Medical versus surgical management for gastro-oesophageal reflux disease (GORD) in adults. Cochrane Database of Systematic Reviews, 153 (3), JC3–JC10. Wyeth (NZ) Limited. (2002). Zoton (lansoprazole) capsules data sheet. www.medsafe.govt.nz/profs/Datasheet/z/zotoncap.htm. Yu-Xiao, Y., Lewis, S. D., Epstein, S. & Metz, D. (2007). Long term proton pump inhibitor therapy and risk of hip fracture. JAMA, 296 , 2947–2953.