McKenna's Pharmacology for Nursing, 2e

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C H A P T E R 4 0 Drugs affecting the female reproductive system

■■ BOX 40.3  Contraceptives: Forms and dosing

Oral contraceptives are available as monophasic, triphasic and quadriphasic. Active tablets generally begin on the fifth day of the cycle (day one of the cycle is the first day of menstrual bleeding). Missed doses. If one tablet is missed, it should be taken as soon as possible, or two tablets taken the next day. Postcoital or emergency contraception (“morning after”). Tablet must be taken within 72 hours after unprotected intercourse. This can be taken as 750 mcg levonorgestrel followed by a second dose 12 hours after the first, or as a 1.5 mg dose. Available emergency contraception includes: Levonelle-1 1.5 mg levonorgestrel Levonelle-2 750 mcg levonorgestrel NorLevo 750 mcg levonorgestrel NorLevo-1 1.5 mg levonorgestrel Postinor-1 1.5 mg levonorgestrel Postinor-2 750 mcg levonorgestrel Monophasic oral contraceptives Brenda-35 ED 2 mg cyproterone acetate, 35 mcg ethinyloestradiol Brevinor 500 mcg norethisterone, 35 mcg ethinyloestradiol Brevinor-1 1 mg norethisterone, 35 mcg ethiny loestradiol Diane-35 ED 2 mg cyproterone acetate, 35 mcg ethinyloestradiol Estelle-35 ED 2 mg cyproterone acetate, 35 mcg ethinyloestradiol Improvil 500 mcg norethisterone, 35 mcg ethinyloestradiol Juliet-35 ED 2 mg cyproterone acetate, 35 mcg ethinyloestradiol Laila-35 ED 2 mg cyproterone acetate, 35 mcg ethinyloestradiol Levlen ED 150 mcg levonorgestrel, 30 mcg ethinyloestradiol Loette 100 mcg levonorgestrel, 20 mcg ethinyloestradiol Marvelon 28 150 mcg desogestrel, 30 mcg ethinyloestradiol Microgynon 20 ED 100 mcg levonorgestrel, 20 mcg ethinyloestradiol Microgynon 30 ED 150 mcg levonorgestrel, 30 mcg ethinyloestradiol Microgynon 50 ED 125 mcg levonorgestrel, 50 mcg ethinyloestradiol Microlevlen ED 100 mcg levonorgestrel, 20 mcg ethinyloestradiol Minulet 75 mcg gestodene, 30 mcg ethinyloestradiol Monofeme 30 mcg ethinyloestradiol, 150 mcg levonorgestrel Nordette 30 mcg ethinyloestradiol, 150 mcg levonorgestrel Norimin 500 mcg norethisterone, 35 mcg ethinyloestradiol

1 mg norethisterone, 35 mcg ethinyloestradiol 1 mg norethisterone, 50 mcg mestranol 30 mcg ethinyloestradiol, 2 mg dienogest 30 mcg ethinyloestradiol, 3 mg drospirenone 20 mcg ethinyloestradiol, 3 mg drospirenone

Norimin-1

Norinyl-1

Valette

Yasmin

Yaz

2.5 mg nomegestrol, 1.5 mg oestadiol

Zoely

Triphasic oral contraceptives Logynon ED Phase 1, 6 tablets: 50 mcg levonorgestrel, 30 mcg ethinyloestradiol; phase 2, 5 tablets: 75 mcg levonorgestrel, 40 mcg ethinyloestradiol; phase 3, 10 tablets: 125 mcg levonorgestrel, 30 mcg ethinyloestradiol Synphasic 28 Phase 1, 7 tablets: 500 mcg norethisterone, 30 mcg ethinyloestradiol; phase 2,

9 tablets: 1 mg norethisterone, 35 mcg ethinyloestradiol; phase 3, 5 tablets: 500 mcg norethisterone, 30 mcg ethinyloestradiol Phase 1, 6 tablets: 50 mcg levonorgestrel, 30 mcg ethinyloestradiol; phase 2, 5 tablets: 75 mcg levonorgestrel, 40 mcg ethinyloestradiol; phase 3, 10 tablets: 125 mcg levonorgestrel, 30 mcg ethinyloestradiol Phase 1, 6 tablets: 50 mcg levonorgestrel, 30 mcg ethinyloestradiol; phase 2,

Trifeme

Triphasil

5 tablets: 75 mcg levonorgestrel, 40 mcg ethinyloestradiol; phase 3, 10 tablets: 125 mcg levonorgestrel, 30 mcg ethinyloestradiol Triquilar ED Phase 1, 6 tablets: 50 mcg levonorgestrel, 30 mcg ethinyloestradiol; phase 2,

5 tablets: 75 mcg levonorgestrel, 40 mcg ethinyloestradiol; phase 3, 10 tablets: 125 mcg levonorgestrel, 30 mcg ethinyloestradiol

Quadriphasic oral contraceptives Qlaira

Phase 1, 2 tablets: 3 mg oestradiol valerate; phase 2: 5 tablets: 2 mg oestradiol valerate, 2 mg dienogest; phase 3, 17 tablets: 2 mg oestradiol valerate, 3 mg dienogest; phase 4, 2 tablets: 1 mg oestradiol valerate

Progestogen-only oral contraceptives Locilan 28 350 mcg norethisterone Microlut 30 mcg levonorgestrel Micronor 350 mcg norethisterone Noriday 28 350 mcg norethisterone

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