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P A R T 3  Drugs acting on the immune system

BIBLIOGRAPHY Cavagna, L., Caporali, R., Trifiro, G., Arcoraci, V., Rossi, S. & Montecucco, C. (2013). Overuse of prescription and OTC non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis and osteoarthritis. International Journal of Immunopathology & Pharmacology, 26, 279–281. Corke, P. (2013). Postoperative pain management. Australian Prescriber, 36, 202–205. D’Arcy, Y. (2011). Prescribing nonsteroidal anti-inflammatory drugs. Nurse Practitioner, 36, 8–11. Dempsey, J., Hillege, S. & Hill, R. (2014). Fundamentals of Nursing and Midwifery: A Person-centred Approach to Care (2nd Australian and New Zealand edn). Sydney: Lippincott Williams & Wilkins. Firth, J. (2011). Rheumatoid arthritis: Treating to target with disease-modifying drugs. British Journal of Nursing, 20, 1240–1245. Firth, J. & Critchley, S. (2011). Treating to target in rheumatoid arthritis: Biologic therapies. British Journal of Nursing, 20, 1284–1291. Fitzgerald, G. A. (2004). Coxibs and cardiovascular disease. New England Journal of Medicine, 351, 1709–1711. Kennedy, D. (2011). Analgesics and pain relief in pregnancy and breastfeeding. Australian Prescriber, 34, 8–10.

Lu, T.Y-T. & Hill, C. (2006). Managing patients taking tumour necrosis factor inhibitors. Australian Prescriber, 29 , 67–70. McKenna, L. (2012). Pharmacology Made Incredibly Easy (1st Australian and New Zealand edn). Sydney: Lippincott Williams & Wilkins. McKenna, L. & Mirkov, S. (2014). McKenna’s Drug Handbook for Nursing and Midwifery (7th edn). Sydney: Lippincott Williams & Wilkins. O’Dell, J. R. (2004). Therapeutic strategies for rheumatoid arthritis. New England Journal of Medicine, 350, 2591–2602. Paul, S. P. & Whibley, J. (2010). Paracetamol prophylaxis: What the evidence says. Practice Nursing, 21, 530–532. Porth, C. M. (2011). Essentials of Pathophysiology: Concepts of Altered Health States (3rd edn). Philadelphia: Lippincott Williams & Wilkins. Porth, C. M. (2009). Pathophysiology: Concepts of Altered Health States (8th edn). Philadelphia: Lippincott Williams & Wilkins. Swaminathan, S. & Riminton, S. (2006). Monoclonal antibody therapy for non-malignant disease. Australian Prescriber, 29, 130–133. Swanson, K. I. & Pfenning, S. (2011). The nurse practitioner’s role in the management of rheumatoid arthritis. Journal for Nurse Practitioners, 7, 858–870. Varghese, M. & Lockey, R. F. (2008). Aspirin-induced asthma. Allergy, Asthma, and Clinical Immunology, 4(2) , 75–83. 4. The NSAIDs affect the COX-1 and COX-2 enzymes. By blocking COX-2 enzymes, the NSAIDs block inflammation and the signs and symptoms of inflammation at the site of injury or trauma. By blocking COX-1 enzymes, these drugs block: a. fever regulation. b. prostaglandins that protect the stomach lining. c. swelling in the periphery. d. liver function. 5. A person has been receiving ibuprofen for many years to relieve the pain of osteoarthritis. Assessment of the person should include:

C H E C K Y O U R U N D E R S T A N D I N G

Answers to the questions in this chapter can be found in Appendix A at the back of this book.

MULTIPLE CHOICE Select the best answer to the following. 1. A drug could be classified as an analgesic if it: a. reduces fever. b. reduces swelling. c. reduces redness. d. reduces pain. 2. An antipyretic is a drug that can: a. block pain. b. block swelling. c. block fever. d. block inflammation. 3. A nurse or midwife might not see a salicylate used as an anti-inflammatory if a drug was needed for its:

a. an electrocardiogram. b. FBC with differential. c. respiratory auscultation. d. renal evaluation.

a. antipyretic properties. b. analgesic properties. c. OTC availability. d. parenteral availability.