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P A R T 2  Chemotherapeutic agents

www.cancernz.org.nz Home page of the Cancer Society of New Zealand. Information on cancer including research, protocols and new information. www.cnsa.org.au Home page of the Cancer Nurses Society of Australia www.ons.org Information about the Oncology Nursing Society. Carrington, C. (2013). Safe use of oral cytotoxic medicines. Australian Prescriber , 36 , 9–12. Chabner, B. A. & Roberts, T. G. (2005). Timeline: Chemotherapy and the war on cancer. Nature Reviews. Cancer , 5 , 65–72. De Vita, V. T., Laurence, T. S. & Rosenberg, S. A. (2011). Cancer: Principles and Practice of Oncology . Philadelphia: Lippincott, Williams & Wilkins. Dempsey, J., Hillege, S. & Hill, R. (2014). Fundamentals of Nursing and Midwifery: A Person-centred Approach to Care (2nd Australian and New Zealand edn). Sydney: Lippincott Williams & Wilkins. Krishnasamy, M., Kwok-Wei, W., Yates, P., de Calvo, L.E.A., Annab, R., Wisniewski, T. & Aranda, S. (2013). The nurse’s MULTIPLE CHOICE Select the best answer to the following. 1. Some properties of neoplastic cells are the same as the properties of normal cells, including: a. anaplasia. b. metastasis. c. mitosis. d. autonomy. 2. Carcinomas are tumours that originate in: a. mesenchyme. b. bone marrow. c. striated muscle. d. epithelial cells. 3. The goal of traditional antineoplastic drug therapy is to: a. reduce the size of abnormal cell mass for immune system destruction. b. eradicate all of the abnormal cells that have developed. c. destroy all cells of the originating type. d. stimulate the immune system to destroy the neoplastic cells. BIBLIOGRAPHY Answers to the questions in this chapter can be found in Appendix A at the back of this book.

role in managing chemotherapy-induced nausea and vomiting: An international survey. Cancer Nursing , DOI: 10.1097/ NCC.0b013e3182a3534a. Liauw, W. S. (2013). Molecular mechanisms and clinical use of targeted anticancer drugs. Australian Prescriber , 36 , 126–131. McKenna, L. (2012). Pharmacology Made Incredibly Easy (1st Australian and New Zealand edn). Sydney: Lippincott Williams & Wilkins. McKenna, L. & Mirkov, S. (2014). McKenna’s Drug Handbook for Nursing and Midwifery (7th edn). Sydney: Lippincott Williams & Wilkins. Middleton, J. & Lennan, E. (2011). Effectively managing chemotherapy-induced nausea and vomiting. British Journal of Nursing , 20 , (sup10) , S7–15. Porth, C. M. (2011). Essentials of Pathophysiology: Concepts of Altered Health States (3rd edn). Philadelphia: Lippincott Williams & Wilkins. Porth, C. M. (2009). Pathophysiology: Concepts of Altered Health States (8th edn). Philadelphia: Lippincott Williams & Wilkins. Priestman, T. (2012). Cancer Chemotherapy in Clinical Practice. London: Springer-Verlag. Roe, H. (2011). Chemotherapy-induced alopecia: Advice and support for hair loss. British Journal of Nursing , 20 (sup5) , 4–11. Schlumeister, L. (2007). Extravasation management. Seminars in Oncology Nursing , 23 , 184–190. Vardy, J. (2008). Neurocognitive effects of chemotherapy in adults. Australian Prescriber , 31 , 22–24. 4. Cancer can be a difficult disease to treat because: a. cells no longer progress through the normal cell cycle. b. cells can develop resistance to drug therapy. c. cells remain dormant, emerging months to years later. d. the exact cause of cancer is not known. 5. Antineoplastic drugs destroy human cells. They are most likely to cause cell death among healthy cells that:

C H E C K Y O U R U N D E R S T A N D I N G

a. have poor cell membranes. b. are rapidly turning over. c. are in dormant tissues. d. cross the blood–brain barrier.

6. Cancer treatment usually occurs in several different treatment phases. In assessing the appropriateness of another round of chemotherapy for a particular person, which of the following would be evaluated as the most important? a. hair loss b. bone marrow function

c. anorexia d. heart rate