McKenna's Pharmacology for Nursing, 2e

995

Index

U Ulcer disease, 897 Unconsciousness, 416, 417 Undecenoic acid, 157 Unstable angina, 713, 715 Upper respiratory tract, 835–836, 843 conditions, 837–838 Upper respiratory tract, drugs acting on, 842–861 adults, 844 antihistamines, 313, 842, 852–856 adverse effects, 855 care considerations, 855–856 contraindications and cautions, 855 drug–drug interactions, 855 pharmacokinetics, 854 therapeutic actions and indications, 854 antitussives, 842, 843–846 adverse effects, 845 care considerations, 845–846 contraindications and cautions, 845 drug–drug interactions, 845 pharmacokinetics, 845 therapeutic actions and indications, 845 children, 844 decongestants. See Decongestants expectorants, 842, 857–859 adverse effects, 858 care considerations, 858–859 contraindications, 858 pharmacokinetics, 857 therapeutic actions and indications, 857 mucolytics, 842, 859–861 adverse effects, 860 care considerations, 860–861 contraindications and cautions, 860 pharmacokinetics, 860 therapeutic actions and indications, 859 older adults, 844 Urea, 950 Ureters, 800 Urethra, 800 Urgency (urinary), 819, 820 Urinary bladder, 800 Urinary frequency, 819, 820 Urinary tract, 800 Urinary tract and bladder, drugs affecting, 819–831 adults, 820 benign prostatic hyperplasia, drugs for, 828–830 adverse effects, 829 care considerations, 830 contraindications and cautions, 829 drug–drug interactions, 829–830 pharmacokinetics, 829 therapeutic actions and indications, 829 bladder protectant (pentosan polysulfate sodium), 826–828 adverse effects, 827 care considerations, 827–828

Tiludronate, 566, 567 Timolol, 477, 478, 676, 958 Tinea, 157 Tinidazole, 172–174 Tinzaparin, 757, 766 Tiotropium, 502, 503, 867, 873

Toxic effects of drugs, 31–39 adverse effects, 31–33 hypersensitivity, 31, 33 primary actions, 32 secondary actions, 32 drug allergy, 31, 33 interventions, 34 drug-induced tissue and organ damage. See Tissue and organ damage, drug-induced Toxicity, 35–36 adrenergic agonist, 461–462

Tipranavir, 137, 139 Tirofiban, 756, 758 Tissue and organ damage, drug induced, 33–39 alterations in glucose metabolism, 36–37 hyperglycaemia, 36–37 hypoglycaemia, 36 auditory damage, 37–38 blood dyscrasia, 31, 35 dermatological reactions, 31, 33–34 rashes and hives, 33–34 stomatitis, 31, 34–35 electrolyte imbalances, 37 hyperkalaemia, 37 hypokalaemia, 37 iatrogenicity, 31, 39 neurological effects, 38 atropine-like (anticholinergic) effects, 38 general central nervous system effects, 38 neuroleptic malignant syndrome, 38 Parkinson-like syndrome, 38 ocular damage, 37 ototoxicity, 37–38 sensory effects, 37–38 superinfections, 31, 35, 81 teratogenicity, 38–39 toxicity, 35–36 liver injury, 36 poisoning, 31, 36 renal injury, 36 TNF (tumour necrosis factor), 235 Tolnaftate, 157, 952 Tolterodine, 824, 825 Tonic-clonic seizure, 352, 355 Topical agents, 949–954 Topical nasal decongestants, 842, 846–849 adverse effects, 846–847 care considerations, 848–849 contraindications and cautions, 846 drug–drug interactions, 847–848 pharmacokinetics, 846 therapeutic actions and indications, 846 Topical nasal steroids, 842, 847, 851–852 adverse effects, 851 care considerations, 851–852 contraindications and cautions, 851 pharmacokinetics, 851 therapeutic actions and indications, 851 Topiramate, 354, 365–368 Topotecan, 222 Toremifene, 212, 215, 609, 614 Tobramycin, 95, 958 Tocilizumab, 265, 266 Tolbutamide, 587 Tolcapone, 382 Tolerance, 25, 27

iron, 784–785 liver injury, 36 poisoning, 31, 36 renal injury, 36 Toxoids, 273, 279–280 Trachea, 835, 836 Trade name, 2, 7 Tramadol, 402 Trandolapril, 662, 665 Transmitter, 16, 17 Transplant holistic care, 268–269 rejection, 238

Tranylcypromine, 323 Trastuzumab, 265, 266 Traveller’s diarrhoea, 923, 924–925 Travoprost, 958 Tretinoin, 223, 953 Triamcinolone, 539, 542, 847, 851, 954 Triamterene, 675, 806, 813 Triazolam, 305, 306 Trichinosis, 179, 181 Trichomoniasis, 163, 172 Tricyclic antidepressants (TCA), 316, 317–322 adverse effects, 321 care considerations, 322 contraindications and cautions, 320 drug–drug interactions, 321–322 pharmacokinetics, 320 therapeutic actions and indications, 317–318, 320 Trifluoperazine, 335, 336, 337 Trimipramine, 317, 318, 320 Triptans, 397, 398, 412 adverse effects, 412 contraindications and cautions, 412 drug–drug interactions, 412 pharmacokinetics, 412 therapeutic actions and indications, 412 Triptorelin, 212, 215 Trophozoites, 163, 165, 170–171 Tropicamide, 958 Tropisetron, 932, 934 Troponin, 643, 646 Trypanosomiasis, 163, 172 Tubular reabsorption, 797 Tubular secretion, 797 Tularaemia, 282 Tumour, 229, 232 Tumour necrosis factor (TNF), 235 Typhoid, 106, 107 vaccine, 279 Tyramine, 316, 324