Handbook of Targeted Cancer Therapy and Immunotherapy

Figure 11.1

107

The tumor microenvironment (TME) of gastrointestinal (GI) cancers. The TME comprises complex interactions between both cellular and soluble components. Cellular cross-talk between immune cells, cancer-associated fibroblasts, and cancer cells can dictate disease progression and therapeutic response. These cellular components additionally secrete soluble factors, like chemokines and cytokines, that further influence the inflammatory TME of GI cancers.

Cancer-Associated Fibroblast (CAF)

Dendritic Cell (DC)

Natural Killer (NK) Cell

Tumor-Associated Macrophage (TAM)

Myeloid-Derived Suppressor Cell (MDSC)

T Cell

B Cell

Cancer Cell

Pericyte

Extracellular Matrix (ECM) Proteins

Chemokines and Cytokines

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