Handbook of Targeted Cancer Therapy and Immunotherapy

Figure 10.1

95

Mechanisms of circulating tumor DNA (ctDNA) release and its applications in the care of gastrointestinal cancer patients. MRD, minimal residual disease.

Applications of ctDNA

Detection of recurrence/MRD

ctDNA is released in circulation via necrosis, apoptosis, active secretion

Prognostic/predictive value

Inform escalation/deescalation of therapy

ctDNA molecule

Monitoring response to therapy

Identification of resistance mechanisms

Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited.