Chi_Principles and Practice of Gynecologic Oncology 8e

Contents xxiii

9.2

Malignant Ovarian Germ Cell Tumors: Etiology, Epidemiology, Risk Factors, Genetics, and Molecular Biology 405 Dimitrios Nasioudis, Emily M. Ko, Koji Matsuo, and Anil K. Sood Ovarian Germ Cell Tumors: Clinical Presentation and Diagnostic Evaluation and Workup 409 Allison M. Puechl, Priya Bhosale, Dimitrios Nasioudis, Emily M. Ko, and Sara Stoneham Surgery for Ovarian Germ Cell Tumors 414 Giorgia Mangili, Deborah Billmire, Dimitrios Nasioudis, and Emily M. Ko Ovarian Germ Cell Tumors: Pathology and Prognostic Factors 420 Elizabeth Euscher and Robert Tucker Burks Therapy for Ovarian Germ Cell Tumors: Radiation, Chemotherapy, Targeted Therapy, Immunotherapy, and Other New and Novel Agents 429 Brenna E. Swift, Dimitrios Nasioudis, and Allan Covens Treatment of Persistent and Recurrent Ovarian Germ Cell Tumors 436 Brenna E. Swift and Allan Covens

SECTION 8 EPITHELIAL OVARIAN CANCER 271 8.1 Epidemiology and Risk Factors 273 Shannon Dawn Armbruster and Ernst Lengyel Hereditary Ovarian Cancer: BRCA and HNPCC—Panel Testing 284 Shannon Dawn Armbruster and Ernst Lengyel 8.2

9.3

8.3

Natural History of the Disease: Patterns of Spread 295 Kathryn A. Mills and Ernst Lengyel Ovarian Cancer: Etiology, Genetics, and Molecular Biology 299 Charles N. Landen Jr and Ernst Lengyel Ovarian Cancer: Clinical Presentation and Diagnostic Workup 310 Ernst Lengyel and Kathryn A. Mills Surgery for Ovarian Cancer 326 Oliver Zivanovic and Ernst Lengyel Ovarian Cancer: Pathology 343 Agnes Julia Bilecz and Ricardo R. Lastra Epithelial Ovarian Cancer: Prognostic Factors 366 Kathryn A. Mills and Ernst Lengyel Management of Early-Stage Ovarian Cancer 371 Katherine C. Kurnit and Gini F. Fleming Management of Borderline Tumors and Low-Grade Serous Tumors 375 Katherine C. Kurnit and Gini F. Fleming Management of Advanced-Stage Ovarian Cancer 378 Katherine C. Kurnit and Gini F. Fleming Approach to Advanced and Recurrent Clear Cell, Mucinous, or Endometrioid Cancer 389 Katherine C. Kurnit and Gini F. Fleming Treatment of Ovarian Carcinosarcoma 391 Katherine C. Kurnit and Gini F. Fleming Ovarian Cancer: Survivorship Issues 392 Katherine C. Kurnit and Gini F. Fleming Treatment of Persistent and Recurrent Ovarian Cancer and Palliative Care 394 Katherine C. Kurnit and Gini F. Fleming

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8.4

9.5

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9.6

8.6

8.7

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8.8

9.8

Ovarian Germ Cell Tumors: Special Conditions 438 Dan Wang and Bradley R. Corr

8.9

9.9

Ovarian Germ Cell Tumors: Follow-Up and Survivorship Issues 440 Olesya Solheim and David M. Gershenson Ovarian Germ Cell Tumors: Future Directions 444 Isabelle Ray-Coquard and Lindsay Frazier

8.10

9.10

8.11

SECTION 10 OVARIAN SEX CORD-STROMAL TUMORS 447 10.1

8.12

Ovarian Sex Cord-Stromal Tumors: Introduction, Anatomy, Natural History, and Patterns of Spread 449 R. Tyler Hillman and Carrie Langstraat Ovarian Sex Cord-Stromal Tumors: Etiology, Epidemiology, Risk Factors, Genetics, and Molecular Biology 450 R. Tyler Hillman Ovarian Sex Cord-Stromal Tumors: Clinical Presentation, Diagnostic Evaluation, and Surgery for Ovarian Sex Cord-Stromal Tumors 456 Carrie Langstraat Ovarian Sex Cord-Stromal Tumors: Pathology and Prognostic Factors 457 Robert H. Young and Barrett Lawson Workup 453 Carrie Langstraat

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8.14

10.2

8.15

10.3

8.16

New Therapeutics 398 Katherine C. Kurnit and Gini F. Fleming

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SECTION 9 OVARIAN GERM CELL TUMORS 401 9.1 Ovarian Germ Cell Tumors: Introduction, Anatomy, Natural History, and Patterns of Spread 403 Dimitrios Nasioudis and Emily M. Ko

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10.5