Chi_Principles and Practice of Gynecologic Oncology 8e

Contents

Preface vii Acknowledgments ix

SECTION 3 VAGINAL CANCER 45 3.1 Vaginal Anatomy 47

Section Editors xi Contributors xiii Video List xix

Diana Miao, Josephine Kang, Amanda Nickles Fader, and Akila N. Viswanathan Vaginal Cancer: Etiology, Epidemiology, Risk Factors, Genetics, and Molecular Biology 49 Diana Miao, Josephine Kang, Amanda Nickles Fader, and Akila N. Viswanathan Symptoms and Diagnosis of Vaginal Intraepithelial Neoplasia and Vaginal Cancer 54 Diana Miao, Josephine Kang, Amanda Nickles Fader, and Akila N. Viswanathan Surgery for Vaginal Intraepithelial Neoplasia and Vaginal Cancer 57 Diana Miao, Josephine Kang, Akila N. Viswanathan, and Amanda Nickles Fader Prognostic Factors 59 Josephine Kang, Diana Miao, Amanda Nickles Fader, and Akila N. Viswanathan Therapeutic Approach for VAIN and Invasive Vaginal Disease 61 Josephine Kang, Diana Miao, Amanda Nickles Fader, and Akila N. Viswanathan Treatment of Persistent and Recurrent Vaginal Cancer 69 Josephine Kang, Diana Miao, Amanda Nickles Fader, and Akila N. Viswanathan Rare Histologies of Vaginal Cancer 70 Josephine Kang, Diana Miao, Amanda Nickles Fader, and Akila N. Viswanathan Vaginal Cancer: Follow-Up, Survivorship Issues, and Summary 78 Diana Miao, Josephine Kang, Amanda Nickles Fader, and Akila N. Viswanathan

SECTION 1 OVERVIEW OF BASIC BIOLOGY 1 1.1 Overview of Basic Biology 3

3.2

Katherine Fuh, Angeles Alvarez Secord, Charles Gourley, and Andrew Berchuck

3.3

SECTION 2 VULVAR CANCER 9 2.1

3.4

Epidemiology of Vulvar Cancer 11 Willemijn L. van der Kolk and M. H. M. Oonk Vulvar Cancer: Anatomy, Natural History, and Patterns of Spread 11 Willemijn L. van der Kolk and M. H. M. Oonk Vulvar Cancer: Etiology, Risk Factors, Genetics, and Molecular Biology 14 Diane C. Ling and Sushil Beriwal Vulvar Cancer: Preinvasive Disease 15 Willemijn L. van der Kolk Vulvar Cancer: Clinical Presentation, Diagnostic Evaluation, and Workup 16 Willemijn L. van der Kolk and M. H. M. Oonk Therapy for Vulvar Cancer: Radiation, Systemic Therapy, and Treatment of Persistent and Recurrent Disease 19 Diane C. Ling and Sushil Beriwal Surgery for Vulvar Cancer 28 Updated by Diane C. Ling and Sushil Beriwal Vulvar Cancer: Pathology and Prognostic Factors 34 Updated by Diane C. Ling and Sushil Beriwal Vulvar Cancer: Follow-Up and Survivorship Issues 43 Diane C. Ling and Sushil Beriwal Vulvar Cancer: Future Directions 44 Diane C. Ling and Sushil Beriwal

2.2

3.5

2.3

3.6

2.4

3.7

2.5

2.6

3.8

3.9

2.7

2.8

SECTION 4 CERVICAL CANCER 81 4.1

Copyright © 2024 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited.

2.9

Cervix Uteri: Epidemiology, Etiology, Risk Factors, Anatomy, Natural History, and Patterns of Spread 83 Teresa K. L. Boitano and Charles A. Leath III

2.10

xxi