Atlas of Pathos Chapter 6

• Diuretics • Angiotensin-converting enzyme inhibitors

Treatment Goal is to avoid target organ damage and complications. • Treatment of underlying cause if secondary HTN • Lifestyle modifications to reduce risk factors

C a r d i o v a s c u l a r D i s o r d e r s

• Alpha-receptor agonists • Beta-adrenergic blockers

BLOOD VESSEL DAMAGE IN HYPERTENSION

Increased intra-arterial pressure damages the endothelium.

Angiotensin II induces endothelial wall con- traction, allowing plasma to leak through interendothelial spaces.

Angiotensin

Plasma constituents deposited in the vessel wall cause medial necrosis.

Fibrinogen Medial necrosis

Platelet

Chapter 6 • Cardiovascular Disorders  69