9788419663085_DeVita. Cancer 12ed.

CON ACTUALIZACIONES TRIMESTRALES Cáncer PRINCIPIOS Y PRÁCTICA DE ONCOLOGÍA DEVITA, HELLMAN & ROSENBERG

12.ª EDICIÓN Vincent T. DeVita, Jr. Theodore S. Lawrence Steven A. Rosenberg

Cáncer DEVITA, HELLMANY ROSENBERG PRINCIPIOSY PRÁCTICA DE LA ONCOLOGÍA

12.ª edición

Editores

Dr. Vincent T. DeVita Jr. Amy and Joseph Perella Professor of Medicine Yale Comprehensive Cancer Center and Smilow Cancer Hospital at Yale–New Haven Professor of Epidemiology and Public Health Yale University School of Public Health New Haven, Connecticut

Theodore S. Lawrence, MD, PhD Isadore Lampe Professor and Chair Department of Radiation Oncology

University of Michigan Ann Arbor, Michigan

Steven A. Rosenberg, MD, PhD Chief, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Professor of Surgery, Uniformed Services University of the Health Sciences School of Medicine Bethesda, Maryland Professor of Surgery, George Washington University School of Medicine Washington, District of Columbia

Con 330 autores colaboradores

Cáncer DEVITA, HELLMANY ROSENBERG PRINCIPIOSY PRÁCTICA DE LA ONCOLOGÍA

12.ª edición

Av. Carrilet, 3, 9.ª planta – Edificio D Ciutat de la Justícia 08902 L’Hospitalet de Llobregat

Barcelona (España) Tel.: 93 344 47 18 Fax: 93 344 47 16 e-mail: consultas@wolterskluwer.com Traducción Wolters Kluwer Revisión científica Jaime G. de la Garza Salazar Investigador clínico del Instituto Nacional de Cancerología, México Paula Juárez Sánchez Ex-Patóloga del Instituto Nacional de Cancerología, México José Luis Maldonado García

Laboratorio de Psicoinmunología, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”; Coordinaciones de Enseñanza y Evaluación de Inmunología, Departamento de Bioquímica, Facultad de Medicina, UNAM; México.

Dirección editorial: Carlos Mendoza Editora de desarrollo: Núria Llavina

Gerente de mercadotecnia: Pamela González Composición: Alfonso Romero/Laura Romero Adaptación de portada: Alberto Sandoval Impresión: QUAD/México

Se han adoptado las medidas oportunas para confirmar la exactitud de la información presentada y describir la práctica más aceptada. No obstante, los autores, los redactores y el editor no son responsables de los errores u omisiones del texto ni de las consecuencias que se deriven de la aplicación de la información que incluye, y no dan ninguna garantía, explícita o implícita, sobre la actualidad, integridad o exactitud del contenido de la publicación. Esta publicación contiene información general relacionada con tratamientos y asistencia médica que no debería utilizarse en pacientes individuales sin antes contar con el consejo de un profesional médico, ya que los tratamientos clínicos que se describen no pueden considerarse recomendaciones absolutas y universales. El editor ha hecho todo lo posible para confirmar y respetar la procedencia del material que se reproduce en este libro y su copyright. En caso de error u omisión, se enmendará en cuanto sea posible. Algunos fármacos y productos sanitarios que se presentan en esta publicación sólo tienen la aprobación de la Food and Drug Administration (FDA) para un uso limitado al ámbito experimental. Compete al profesional sanitario averiguar la situación de cada fármaco o producto sanitario que pretenda utilizar en su práctica clínica, por lo que aconsejamos la consulta con las autoridades sanitarias competentes. Derecho a la propiedad intelectual (C. P. Art. 270) Se considera delito reproducir, plagiar, distribuir o comunicar públicamente, en todo o en parte, con ánimo de lucro y en perjuicio de terceros, una obra literaria, artística o científica, o su transformación, interpretación o ejecución artística fijada en cualquier tipo de soporte o comunicada a través de cualquier medio, sin la autorización de los titulares de los correspondientes derechos de propiedad intelectual o de sus cesionarios. Reservados todos los derechos. Copyright de la edición en español © 2024 Wolters Kluwer ISBN edición en español: 978-84-19663-08-5 Depósito legal: M-27363-2023 Edición en español de la obra original en lengua inglesa DeVita, Hellman, and Rosenberg's Cancer , 12th edition, de Vincent T. DeVita Jr., Theodore S. Lawrence y Steven A. Rosenberg, publicada por Wolters Kluwer Copyright © 2023 Wolters Kluwer Two Commerce Square 2001 Market Street Philadelphia, PA 19103 ISBN edición original: 978-1-9751-8468-1

A U T O R E S COLABORADORES

Nadeem R. Abu-Rustum, MD Chief, Gynecology Service Department of Surgery Memorial Sloan Kettering Cancer Center New York, New York Mohamed Abdelgadir Adam, MD Assistant Professor of Surgery Department of Surgery, Division of Surgical Oncology University of California, San Francisco San Francisco, California Narasimhan P. Agaram, MBBS Attending Pathologist Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center New York, New York Manmeet S. Ahluwalia, MD, MBA Chief of Medical Oncology, Chief Scientific Officer, Deputy Director Miami Cancer Institute Miami, Florida Kaled M. Alektiar, MD Attending Physician Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York Stephen Ansell, MD, PhD Charlotte E. Ariyan, MD, PhD Associate Attending Memorial Sloan Kettering Cancer Center New York, New York Álvaro Arjona-Sánchez, MD, PhD Consultant in Surgical Oncology Unit of Surgical Oncology, Department of Surgery Reina Sofia University Hospital Cordoba, Spain Alan Ashworth, PhD, FRS President, UCSF Helen Diller Family Comprehensive Cancer Center University of California, San Francisco San Francisco, California Professor of Medicine Division of Hematology Mayo Clinic Rochester, Minnesota

Jon C. Aster, MD, PhD Deputy Chair Department of Pathology Brigham and Women’s Hospital

Tracy Batchelor, MD Chair Department of Neurology Brigham and Women’s Hospital Harvard Medical School Boston, Massachusetts Matthew A. Beier, BS, MFE Rutgers Robert Wood Johnson Medical School Chief, Pain and Palliative Care Service National Institutes of Health Clinical Center Bethesda, Maryland Sushil Beriwal, MD, MBA, FASTRO, FABS Academic Chief Department of Radiation Oncology New Brunswick, New Jersey Ann M. Berger, MSN, MD Senior Research Clinician Director of Gynecologic Oncology Brigham and Women’s Hospital and Dana-Farber Cancer Institute William H. Baker Professor of Gynecology Harvard Medical School Boston, Massachusetts Jan H. Beumer, PharmD, PhD, DABT Professor of Pharmaceutical Sciences and Medicine UPMC Hillman Cancer Center University of Pittsburgh School of Pharmacy Pittsburgh, Pennsylvania Aarti Bhatia, MD, MPH Assistant Professor Department of Internal Medicine, Division of Oncology Yale School of Medicine New Haven, Connecticut Leonardo Kayat Bittencourt, MD, PhD Vice-Chair of Innovation, Associate Professor of Radiology Department of Radiology University Hospitals and Case Western Reserve University Cleveland, Ohio Allegheny Health Network Pittsburgh, Pennsylvania Ross S. Berkowitz, MD

Boston, Massachusetts David A. August, MD Professor of Surgery

Associate Director, Faculty Affairs Department of Surgery, Division of Surgical Oncology Rutgers Cancer Institute of New Jersey Rutgers Robert Wood Johnson Medical School New Brunswick, New Jersey Itzhak Avital, Bsc MD, MBA, FACS Executive Medical Director, Chairman of Surgery Legacy Heritage Oncology Center Ben Gurion University Beer Sheva, Israel Joachim M. Baehring, MD, DSc Professor Department of Neurology and Neurosurgery Yale School of Medicine New Haven, Connecticut Laurence Baker, DO, FACOI Collegiate Professor Department of Internal Medicine and Pharmacology University of Michigan Ann Arbor, Michigan Ting Bao, MD, DABMA, MS Director, Integrative Breast Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Christopher A. Barker, MD Associate Attending and Vice-Chair of Clinical Research Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York Ronald D. Barr, CM, MB, ChB, MD Professor Emeritus Department of Pediatrics and Medicine McMaster University Hamilton, Ontario, Canada

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AUTORES COLABORADORES

Elizabeth M. Blanchard, MD Chief Department of Hematology and Oncology Southcoast Health New Bedford, Massachusetts

Justin C. Brown, PhD Director, Cancer Metabolism Program Pennington Biomedical Research Center Baton Rouge, Louisiana

Keith A. Casper, MD Associate Professor Department of Otolaryngology—Head and Neck Surgery

University of Michigan Ann Arbor, Michigan

Archie Bleyer, MD Clinical Research Professor

Harold J. Burstein, MD, PhD Professor of Medicine Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts

Sharon M. Castellino, MD, MSc Professor of Pediatrics Director, Leukemia/Lymphoma Program Department of Pediatrics

Department of Radiation Medicine Oregon Health & Science University Portland, Oregon Professor of Pediatrics University of Texas McGovern Medical School Houston, Texas Sharon L. Bober, PhD Psychologist Director, Sexual Health Program Department of Psychosocial Oncology and Palliative Care Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts Lawrence H. Boise, PhD R. Randall Rollins Professor in Cancer Research Department of Hematology and Medical Oncology Winship Cancer Institute of Emory University Atlanta, Georgia Danielle C. Bonadies, MS, CGC CoFounder and Director My Gene Counsel New Haven, Connecticut Steven E. Braunstein, MD, PhD Associate Professor Department of Radiation Oncology University of California San Francisco San Francisco, California Otis W. Brawley, MD Bloomberg Distinguished Professor Department of Oncology and Epidemiology The Johns Hopkins University School of Medicine Baltimore, Maryland Jonathan R. Brody, PhD Vice Chair of Research Department of Surgery Associate Director of the Brenden-Colson Center for Pancreatic Care Department of Surgery and Cell, Development, and Cancer Biology Oregon Health and Science University Portland, Oregon Department of Reproductive Endocrinology and Infertility National Institute of Child Health and Human Development National Institutes of Health Bethesda, Maryland Marja Brolinson, MD Clinical Fellow

Emory University Atlanta, Georgia

Isabella F. Calastri, BSN Department of Professional Nursing Practice Georgetown University School of Nursing and Health Studies Washington, District of Columbia Teresa Calimeri, MD, PhD Physician Lymphoma Unit IRCCS San Raffaele Scientific Institute Milan, Italy Robert B. Cameron, MD Professor of Cardiothoracic Surgery and Surgical Oncology Department of Surgery David Geffen School of Medicine at University of California, Los Angeles Los Angeles, California Matthew T. Campbell, MD, MS Assistant Professor, Associate Medical Director Genitourinary Center Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer Center Houston, Texas Michele Carbone, MD, PhD William & Ellen Melohn Chair in Cancer Biology Director, Thoracic Oncology University of Hawaii Cancer Center Professor, Department of Pathology John A. Burns School of Medicine Honolulu, Hawaii Paolo G. Casali, MD Director of Medical Oncology Unit 2 Associate Professor Fondazione IRCCS Istituto Nazionale dei Tumori University of Milan Milan, Italy Neil S. Horowitz, MD Assistant Professor of Obstetrics, Gynecology, and Reproductive Medicine Harvard Medical School Co-Director, New England Trophoblastic Disease Center Division of Gynecologic Oncology Brigham and Women’s Hospital Dana-Farber Cancer Institute Boston, Massachusetts

Debyani Chakravarty, PhD Assistant Attending Molecular Geneticist, Molecular Diagnostics Service Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center New York, New York Ronald Chamberlain, MD, MPA, FACS Chief, Surgical Oncology and HPB Surgery Department of Surgery HCA West Florida and USF Morgani School of Medicine Tampa, Florida Richard Champlin, MD Chairman, Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston, Texas Étienne Chatelut, PharmD, PhD Professor of Pharmacology Faculté de Santé, Department de Pharmacie Institut Universitaire du Cancer de Toulouse Toulouse, France Bhishamjit S. Chera, MD Professor of Radiation Oncology and Otolaryngology, Head and Neck Surgery Wendy & Keith Wellin Endowed Chair Department of Radiation Oncology Medical University of South Carolina Charleston, South Carolina Nathan I. Cherny, AM, MBBS, FRACP, FRCP, LLD Director, Cancer Pain and Palliative Medicine Service Department of Medical Oncology and Palliative Care Shaare Zedek Medical Center Jerusalem, Israel Brooke O. Cherven, PhD, MPH, RN Assistant Professor of Pediatrics Aflac Cancer and Blood Disorders Center

Emory University Atlanta, Georgia

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AUTORES COLABORADORES

Lydia L. Chevalier, PhD Research Fellow, Perini Family Survivors’ Center Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts Lauren Chiec, MD Hematology and Oncology Fellow Department of Medicine McGaw Medical Center of Northwestern University Chicago, Illinois Edward Chow, MBBS, MSc, PhD, FRCPC Radiation Oncologist Department of Radiation Oncology University of Toronto Toronto, Ontario, Canada Edward Chu, MD, MMS Director Vice-President of Cancer Medicine, Montefiore Medicine Montefiore Einstein Cancer Center Albert Einstein College of Medicine Bronx, New York Melvin Lee Kiang Chua, MBBS, FRCR, PhD, FAMS Head and Senior Consultant Department of Head and Neck and Thoracic Cancers Division of Radiation Oncology National Cancer Centre Singapore Callisia N. Clarke, MD, MS, FACS, FSSO Assistant Professor of Surgery Department of Surgery, Division of Surgical Oncology Medical College of Wisconsin Milwaukee, Wisconsin Sean R. Christensen, MD, PhD Associate Professor Department of Dermatology Yale School of Medicine New Haven, Connecticut

Louis S. Constine, MD, FASTRO, FACR Professor of Radiation Oncology and Pediatrics University of Rochester Medical Center Rochester, New York Mehmet Sitki Copur, MD, FACP Medical Director, Morrison Cancer Center Medical Oncology Morrison Cancer Center Mary Lanning Healthcare, Hastings, Nebraska Professor, University of Nebraska Medical Center Department of Medicine Division of Hematology Oncology, Adjunct Faculty Omaha, Nebraska Anne M. Covey, MD, FSIR Professor of Radiology, Attending Radiologist Department of Radiology Memorial Sloan Kettering Cancer Center Weill Cornell Medical Center New York, New York Aimee M. Crago, MD, PhD, FACS Associate Attending Surgeon Department of Gastric and Mixed Tumor Service Memorial Sloan Kettering Cancer Center New York, New York Tracy E. Crane, PhD, RDN Co-lead, Cancer Control Director of Digital Health and Lifestyle Medicine for Cancer Survivorship Sylvester Comprehensive Cancer Center University of Miami, Leonard M. Miller School of Medicine Miami, Florida Department of Radiation Oncology Duke University Medical Center Durham, North Carolina Douglas M. Dahl, MD Chief, Division of Urologic Oncology Department of Urology Massachusetts General Hospital Boston, Massachusetts Peter T. Dziegielewski, MD, FRCSC Chief of Head and Neck Surgical Oncology and Microvascular Reconstructive Surgery Department of Otolaryngology Andrés F. Correa, MD Assistant Professor Department of Urologic Oncology Fox Chase Cancer Center Philadelphia, Pennsylvania Brian G. Czito, MD Professor

Sandra P. D’Angelo, MD Research Director, Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Catherine Hambleton Davis, MD, MPH Fellow, Complex General Surgical Oncology Department of Surgical Oncology Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey Lorraine T. Dean, ScD Associate Professor Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore, Maryland Alan H. DeCherney, MD Branch Chief, Reproductive Endocrinology and Gynecology National Institute of Child Health and Human Development National Institutes of Health Bethesda, Maryland

Angelo Paolo DeiTos, MD Professor of Pathology Chair

Department of Integrated Diagnostics University of Padua School of Medicine Padua, Italy

Marcos de Lima, MD Professor of Medicine Department of Hematology Ohio State University Columbus, Ohio

Marcello Deraco, MD Director of Peritoneal Surface Malignancies Unit Department of Surgical Oncology Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Italy

Hari A. Deshpande, MD, MBChB Associate Professor of Medicine Department of Medical Oncology Yale Cancer Center

Erin F. Cobain, MD Assistant Professor Department of Internal Medicine

Yale School of Medicine New Haven, Connecticut

University of Michigan Ann Arbor, Michigan

Jessica S. Donington, MD, MSCr Professor and Chief of Thoracic Surgery Department of Surgery, Section of Thoracic Surgery University of Chicago Medicine Chicago, Illinois Benjamin J. Drapkin, MD, PhD Assistant Professor Department of Internal Medicine University of Texas Southwestern Medical Center Dallas, Texas

Robert E. Coleman, MBBS, MD, FRCP Emeritus Professor of Medical Oncology Department of Oncology and Metabolism University of Sheffield Sheffield, United Kingdom

Annette Compter, MD, PhD Neuro-Oncologist Department of Neurology Antoni van Leeuwenhoek Amsterdam, Netherlands

College of Medicine University of Florida Gainesville, Florida

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AUTORES COLABORADORES

100

Frank C. Detterbeck, MD Professor and Chief, Thoracic Surgery

Jason A. Efstathiou, MD, DPhil, FASTRO, FACRO Professor, Harvard Medical School Director, Genitourinary Division Department of Radiation Oncology Massachusetts General Hospital Boston, Massachusetts Matthew J. Ehrhardt, MD, MS Assistant Member Department of Oncology Department of Epidemiology and Cancer Control St. Jude Children’s Research Hospital Memphis, Tennessee Kevin M. Elias, MD, FACOG Director of the Gynecologic Oncology Laboratory Division of Gynecologic Oncology Department of Obstetrics and Gynecology and Reproductive Biology

Jane M. Fall-Dickson, PhD, MSN, RN Associate Professor Assistant Chair, Research Department of Professional Nursing Practice Georgetown University School of Nursing and Health Studies Washington, District of Columbia Meagan B. Farmer, MS, MBA, LCGC Director, Genetic Clinical Operations

Department of Surgery Yale School of Medicine New Haven, Connecticut

Khanh T. Do, MD Director, Clinical Development Department of Oncology Division of Cancer Treatment and Diagnosis National Cancer Institute National Institutes of Health Moderna, Incorporated Cambridge, Massachusetts

Department of Genetics My Gene Counsel, LLC New Haven, Connecticut

Adam S. Feldman, MD, MPH Assistant Professor of Surgery Department of Urology Massachusetts General Hospital Harvard Medical School Boston, Massachusetts

Siddhartha Devarakonda, MD Assistant Professor of Medicine Department of Internal Medicine Washington University School of Medicine St. Louis, Missouri Vincent T. DeVita Jr., MD Amy and Joseph Perella Professor of Medicine Yale Comprehensive Cancer Center and Smilow Cancer Hospital at Yale–New Haven Professor of Epidemiology and Public Health Yale University School of Public Health New Haven, Connecticut Ahmet Dogan, MD, PhD Chief, Department of Pathology Memorial Sloan Kettering Cancer Center New York, New York Alexander Drilon, MD Chief, Early Drug Development Memorial Sloan Kettering Cancer Center New York, New York Steven G. DuBois, MD, MS Associate Professor Department of Pediatrics Harvard Medical School Dana-Farber Cancer Institute Boston, Massachusetts Lara A. Dunn, MD Assistant Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Shruti Jolly, MD Professor Department of Radiation Oncology

Andrea Ferrari, MD Pediatric Oncology Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Italy Renata Ferrarotto, MD Associate Professor Department of Thoracic Head and Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston, Texas Andrés José María Ferreri, MD Doctor Lymphoma Unit IRCCS San Raffaele Scientific Institute Milano, Italy Paul T. Finger, MD, FACS Director, The New York Eye Cancer Center Clinical Professor of Ophthalmology Department of Ophthalmology NYU Grossman School of Medicine New York, New York Joel A. Finkelstein, MD, MSc, FRCSC Associate Professor

Brigham and Women’s Hospital Dana-Farber Cancer Institute Assistant Professor Harvard Medical School Boston, Massachusetts

Tobias Else, MD Associate Professor Department of Internal Medicine Division of Metabolism, Endocrinology and Diabetes

University of Michigan Ann Arbor, Michigan

Cathy Eng, MD, FACP, FASCO David H. Johnson Endowed Chair in Surgical and Medical Oncology Professor of Medicine, Hematology and Oncology Co-Director, GI Oncology Co-Leader, Gastrointestinal Cancer Research Program Director, Young Adult Cancers Program Co-Chair, NCI Gastrointestinal Steering Committee Vanderbilt-Ingram Cancer Center Nashville, Tennessee Douglas B. Evans, MD Donald C. Ausman Family Foundation Professor of Surgery Chair, Department of Surgery Medical College of Wisconsin Milwaukee, Wisconsin Joseph R. Evans, MD, PhD Assistant Professor Department of Radiation Oncology

Department of Surgery University of Toronto Toronto, Ontario, Canada

Allison Fitzgerald, PhD Department of Oncology Georgetown University Washington, District of Columbia

Glenn J. Hanna, MD Medical Oncologist, Assistant Professor of Medicine Center for Salivary and Rare Head and Neck Cancers Center for Head and Neck Oncology Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts

University of Michigan Ann Arbor, Michigan

University of Michigan Ann Arbor, Michigan

Mary Feng, MD Professor

Michael Girardi, MD Professor and Vice Chair Department of Dermatology Yale School of Medicine New Haven, Connecticut

Department of Radiation Oncology University of California, San Francisco San Francisco, California

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AUTORES COLABORADORES

Yuman Fong, MD Sangiacomo Chair and Chairman Department of Surgery City of Hope National Medical Center Duarte, California Meera Hameed, MD Attending Pathologist, Chief of Service, Surgical Pathology Department of Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center New York, New York Francine M. Foss, MD Professor of Medicine Department of Hematology and Stem Cell Transplantation

Nicolas Girard, MD, PhD Head, Thorax Institute Curie- Montsouris Institute Curie Paris, France Olivier Glehen, MD, PhD Professor of Surgery Department of Surgical Oncology Centre Hospitalo-Universitaire Lyon Sud Pierre-Bénite, France Diane Goéré, MD, PhD Professor Department of Digestive Surgery Hôpital Saint Louis Université Paris Diderot Paris, France Matthew P. Goetz, MD Erivan K. Haub Family Professor Professor of Oncology and Pharmacology Department of Medical Oncology Mayo Clinic Rochester, Minnesota Stephanie L. Goff, MD, FACS Associate Research Physician Center for Cancer Research/Surgery Branch National Cancer Institute National Institutes of Health Bethesda, Maryland Sara B. Goldberg, MD, MPH Associate Professor Department of Medicine, Division of Medical Oncology Leonard G. Gomella, MD, FACS Professor and Chairman Department of Urology Thomas Jefferson University Philadelphia, Pennsylvania Karyn A. Goodman, MD, MS Professor Department of Radiation Oncology Icahn School of Medicine at Mount Sinai New York, New York Ramaswamy Govindan, MD Professor of Medicine Department of Medicine Washington University School of Medicine St. Louis, Missouri Jennifer J. Griggs, MD, MPH Professor Department of Internal Medicine, Division of Hematology/Oncology Yale School of Medicine New Haven, Connecticut

Alessandro Gronchi, MD Chair, Sarcoma Service Department of Surgery Fondazione IRCCS Istituto Nazionale dei Tumori Milan, Italy Vikas A. Gupta, MD, PhD Assistant Professor Department of Hematology and Medical Oncology Winship Cancer Institute of Emory University Atlanta, Georgia Daphne A. Haas-Kogan, MD Chair Department of Radiation Oncology

Yale School of Medicine New Haven, Connecticut

Brigham and Women’s Hospital Dana-Farber Cancer Institute Boston Children’s Hospital Boston, Massachusetts Stephanie Halene, MD Associate Professor Chief, Section of Hematology Yale Cancer Center Yale School of Medicine New Haven, Connecticut

Deshka Foster, MD, PhD Department of Surgery Stanford University School of Medicine Stanford, California

Steven J. Frank, MD The Bessie McGoldrick Professorship in Clinical Cancer Research Executive Director, Particle Therapy Institute Deputy Head, Strategic Programs Division of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston, Texas Scott Nicholas Furlan, MD Assistant Professor Clinical Research Division Fred Hutchinson Cancer Research Center

Gary D. Hammer, MD, PhD Millie Schembechler Professor of Adrenal Cancer Director, Endocrine Oncology Program Department of Internal Medicine/MEND Christine L. Hann, MD, PhD Associate Professor of Oncology The Johns Hopkins University School of Medicine Baltimore, Maryland Ehab Y. Hanna, MD, FACS Professor and Vice Chairman Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston, Texas Aphrothiti J. Hanrahan, PhD Assistant Lab Member Department of Human Oncology and Pathogenesis Program (HOPP) Memorial Sloan Kettering Cancer Center New York, New York Roy S. Herbst, MD, PhD Chief of Medical Oncology and Deputy Director for Clinical Affairs Yale Cancer Center Assistant Dean for Translational Research University of Michigan Ann Arbor, Michigan

Department of Pediatrics University of Washington Seattle, Washington

Nicolette M. Gabel, PhD Associate Professor Department of Physical Medicine and Rehabilitation

University of Michigan Ann Arbor, Michigan

Carlo Gambacorti-Passerini, MD Director, Department of Hematology University of Milano Bicocca San Gerardo Hospital Monza, Italy Nasrin Ghalyaie, MD, FACS, FASCRS Colon and Rectal Surgeon HCA Affiliated Hospitals Tampa, Florida

Michael Jaglal, MD, MS Associate Professor Moffitt Cancer Center Tampa, Florida

University of Michigan Ann Arbor, Michigan

Yale School of Medicine New Haven, Connecticut

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AUTORES COLABORADORES

James G. Herman, MD Professor Department of Medicine, Hematology Oncology UPMC Hillman Cancer Center University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania Paul J. Hesketh, MD, FASCO Director, Lahey Health Cancer Institute Lahey Hospital and Medical Center Burlington, Massachusetts Geoffrey R. Hill, MD Director of Hematopoietic Stem Cell Transplantation Clinical Research Division Fred Hutchinson Cancer Research Center Seattle, Washington Christopher J. Hoimes, DO Associate Professor Genitourinary Oncology Associate Director for Developmental Therapeutics, Center for Cancer Immunotherapy Department of Medicine, Genitourinary Oncology Duke Cancer Institute, Duke University School of Medicine Durham, North Carolina Christina Huang, MD, MS Department of Radiation Oncology Duke University School of Medicine Durham, North Carolina Mark D. Hurwitz, MD Chair and Director, Department of Radiation Medicine New York Medical College, Westchester Medical Center Valhalla, New York David H. Ilson, MD, PhD Professor Gastrointestinal Oncology Service Department of Medicine Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York, New York Gopa Iyer, MD Associate Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Kayla Weiss Miranda, MD Department of Internal Medicine Vanderbilt University Medical Center Nashville, Tennessee William C. Jackson, MD Assistant Professor Department of Radiation Oncology

Caron A. Jacobson, MD Assistant Professor of Medicine Department of Medical Oncology Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts

Matthew F. Kalady, MD Professor of Surgery Director, Division of Colon and Rectal Surgery Department of Surgery The Ohio State Wexner Medical Center The James Comprehensive Cancer Center Columbus, Ohio Arif H. Kamal, MD, MBA, MHS Associate Professor Division of Medical Oncology and Section of Palliative Care Duke Cancer Institute Durham, North Carolina Jose A. Karam, MD, FACS Associate Professor Department of Urology and Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Houston, Texas Partow Kebriaei, MD Professor Department of Stem Cell Transplant and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston, Texas Jacqueline R. Kelly, MD, MSc Radiation Oncologist Morrison Cancer Center Mary Lanning Healthcare, Hastings, Nebraska Adjunct Professor in the College of Allied Health Professions, Division of Radiation Therapy Program University of Nebraska Medical Center Omaha, Nebraska Tari A. King, MD Chief, Division of Breast Surgery Anne E. Dyson Professor of Surgery in the Field of Women’s Cancers Department of Surgery Brigham and Women’s Hospital Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts David G. Kirsch, MD, PhD Barbara Levine University Professor Department of Radiation Oncology Duke University School of Medicine Durham, North Carolina Ann S. LaCasce, MD, MMSc Associate Professor of Medicine Dana-Farber Cancer Institute Boston, Massachusetts Philipp Karschnia, MD Department of Neurosurgery Ludwig-Maximilians-University Munich, Germany

Reshma Jagsi, MD, DPhil Newman Family Professor, Department of Radiation Oncology Director, Center for Bioethics and Social Sciences in Medicine

University of Michigan Ann Arbor, Michigan

Ahmedin Jemal, DVM, PhD Senior Vice President Surveillance and Health Equity Science American Cancer Society Atlanta, Georgia Erel Joffe, MD, MSc Attending Department of Medicine, Lymphoma Service Memorial Sloan Kettering Cancer Center New York, New York Douglas B. Johnson, MD, MSCI Assistant Professor of Medicine Vanderbilt University School of Medicine Nashville, Tennessee Peter W.M. Johnson, MD, FRCP, FMedSci Professor of Medical Oncology School of Cancer Sciences, Faculty of Medicine University of Southampton Southampton, United Kingdom Kirsten Jorgensen, MD Gynecologic Oncology Fellow Department of Gynecologic Oncology and Reproductive Medicine The University of Texas MD Anderson Cancer Center Houston, Texas Nisha S. Joseph, MD Assistant Professor Department of Hematology and Medical Oncology Winship Cancer Institute, Emory University Atlanta, Georgia Michelle M. Kim, MD Associate Professor Department of Radiation Oncology

University of Michigan Ann Arbor, Michigan

W. Kevin Kelly, DO Professor Department of Medical Oncology and Urology

Michigan Medicine Ann Arbor, Michigan

Thomas Jefferson University Philadelphia, Pennsylvania

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AUTORES COLABORADORES

Ann H. Klopp, MD, PhD Professor

Sheila Lahijani, MD Associate Clinical Professor Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Palo Alto, California Theodore S. Lawrence, MD, PhD Isadore Lampe Professor and Chair Department of Radiation Oncology Yaacov Richard Lawrence, MBBS, MA, MRCP Vice Chair and Director, Center for Translational Research in Radiation Oncology Department of Radiation Oncology Sheba Medical Center, Affiliated with Tel Aviv University Ramat Gan, Israel University of Michigan Ann Arbor, Michigan

Lawrence Leichman, MD Clinical Professor of Medicine Director, Solid Tumor Oncology Bellevue Hospital Department of Medicine New York University Grossman School of Medicine New York, New York Antonio Marcondes Lerario, MD, PhD Assistant Research Scientist Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes Rebecca A. Levine, MD Assistant Professor of Surgery Department of Surgery Montefiore Medical Center Albert Einstein College of Medicine Bronx, New York Akeem R. Lewis, MD Medical Oncology Fellow Department of Medical Oncology Mayo Clinic Rochester, Minnesota Daneng Li, MD Assistant Professor Department of Medical Oncology and Therapeutics Research City of Hope Comprehensive Cancer Center Duarte, California Jennifer A. Ligibel, MD Associate Professor of Medicine Department of Medical Oncology Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts W. Marston Linehan, MD Chief, Urologic Oncology Branch National Cancer Institute National Institutes of Health Bethesda, Maryland Brigette B.Y. Ma, MD, MBBS, FRACP, FHKCP, FHKAM Professor Department of Clinical Oncology The Chinese University of Hong Kong Shatin, Hong Kong, SAR Stephen T. Magill, MD, PhD Assistant Professor Department of Neurological Surgery Northwestern University Feinberg School of Medicine Chicago, Illinois University of Michigan Ann Arbor, Michigan

Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston, Texas Rupesh Kotecha, MD Chief of Radiosurgery, Director of CNS Metastasis Department of Radiation Oncology Miami Cancer Institute Baptist Health South Florida Miami, Florida Anupam Kotwal, MD Assistant Professor of Medicine Department of Diabetes, Endocrinology, and Metabolism University of Nebraska Medical Center Omaha, Nebraska Sunil Krishnan, MD Professor Department of Radiation Oncology Mayo Clinic Jacksonville, Florida Robert S. Krouse, MD, MDMS Professor of Surgery Department of Surgery University of Pennsylvania Philadelphia, Pennsylvania Chaoyuan Kuang, MD, PhD Assistant Professor Department of Oncology Montefiore Einstein Cancer Center Albert Einstein College of Medicine Bronx, New York Shaji Kumar, MD Mark and Judy Mullins Professor of Hematological Malignancies Division of Hematology Mayo Clinic Rochester, Minnesota Shivaani Kummar, MD, FACP DeArmond Endowed Chair of Cancer Research Professor and Head, Division of Hematology and Medical Oncology Associate Director for Clinical and Translational Research Co-Director, Center for Experimental Therapeutics Knight Cancer Institute Oregon Health and Science University Portland, Oregon Brian R. Lane, MD, PhD, FACS Betz Family Endowed Chair for Cancer Research Professor, Division of Urology Spectrum Health: Michigan State University College of Human Medicine Grand Rapids, Michigan

Matt Lechner, MD, PhD Associate Professor (Honorary) UCL Cancer Institute University College London London, United Kingdom

Philipp D. le Coutre, MD Professor Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie Charité Humboldt-Universität Berlin Berlin, Germany Percy P. Lee, MD Section Chief, Thoracic Radiation Oncology Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston, Texas

Richard J. Lee, MD, PhD Assistant Professor Department of Medicine Harvard Medical School Boston, Massachusetts

David J. Leffell, MD, CM David Paige Smith Professor of Dermatology and Surgery Department of Dermatologic Surgery

Yale School of Medicine New Haven, Connecticut Sam Lubner, MD, FACP Associate Professor Department of Medicine UW Carbone Cancer Center University of Wisconsin Madison, Wisconsin

Ofer Margalit, MD, PhD Senior Physician Institute of Oncology Sheba Medical Center Ramat Gan, Israel

Steven K. Libutti, MD, FACS Director Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey

xii

AUTORES COLABORADORES

Ajay V. Maker, MD, FACS, FSSO Professor and Chief of Surgical Oncology Maurice Galante Distinguished Professor in Surgical Oncology Department of Surgery University of California San Francisco San Francisco, California Vicki Makker, MD Associate Attending Physician Department of Medicine, GYN Medical Oncology Service Memorial Sloan Kettering Cancer Center New York, New York J. Logothetis, MD Professor Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer Center Houston, Texas Jun J. Mao, MD, MSCE Laurance S. Rockefeller Chair in Integrative Medicine Chief, Integrative Medicine Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York J. Ryan Mark, MD Assistant Professor Department of Urology Sidney Kimmel Cancer Institute at Thomas Jefferson University Philadelphia, Pennsylvania Rachael Maynard, MD, PhD Candidate Georgetown University School of Medicine Washington, District of Columbia William M. Mendenhall, MD, FACR, FASTRO Professor Department of Radiation Oncology University of Florida College of Medicine Gainesville, Florida Jeffrey A. Meyerhardt, MD, MPH Professor of Medicine Department of Medical Oncology Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts Mitchell C. Posner, MD, FACS Thomas D. Jones Professor of Surgery and Vice-Chairman Chief, Section of General Surgery and Surgical Oncology Department of Surgery University of Chicago Medicine Chicago, Illinois Ellen T. Matloff, MS, CGC President and CEO My Gene Counsel New Haven, Connecticut

Michelle L. Mierzwa, MD Associate Professor Department of Radiation Oncology

Bradley J. Monk, MD, FACS, FACOG Professor of Gynecologic Oncology University of Arizona College of Medicine Creighton University School of Medicine Director, Principal Investigator, Community Research Development HonorHealth Research Institute Vice President and Member Board of Directors, GOG-Foundation Co-director, GOG-Partners Phoenix, Arizona Susan M. O’Brien, MD Professor of Medicine Chao Family Comprehensive Cancer Center University of California, Irvine Irvine, California Jeffrey A. Norton, MD Professor of Surgery Department of Surgery Stanford University School of Medicine Stanford, California Daniel Morgensztern, MD Professor of Medicine Clinical Director of Thoracic Oncology Department of Medicine Washington University School of Medicine St. Louis, Missouri C. Mueller, MD, PhD Instructor Department of Radiation Oncology Richard J. O’Donnell, MD, FAAOS Professor of Clinical Orthopaedic Surgery Chief, Orthopaedic Oncology Service Director, Sarcoma Program Director, Musculoskeletal Research Consortium Director, International Center for Osseointegration Research, Education, and Surgery Department of Orthopaedic Surgery University of California, San Francisco San Francisco, California Franco M. Muggia, BA, MD † Professor of Medicine Department of Oncology New York University School of Medicine New York, New York Graham W. Warren, MD, PhD Professor, Mary Gilbreth Endowed Chair of Oncology Vice Chairman, Research in Radiation Oncology Department of Radiation Oncology Department of Cell and Molecular Pharmacology and Experimental Therapeutics Medical University of South Carolina Charleston, South Carolina Thomas Jefferson University Philadelphia, Pennsylvania

University of Michigan Ann Arbor, Michigan

John D. Minna, MD Director, Hamon Center for Therapeutic Oncology Research Professor, Internal Medicine and Pharmacology University of Texas Southwestern Medical Center Dallas, Texas Sandra A. Mitchell, PhD, CRNP, AOCN, FAAN Senior Scientist Outcomes Research Branch Healthcare Delivery Research Program Division of Cancer Control and Population Sciences National Cancer Institute National Institutes of Health Rockville, Maryland David T. Miyamoto, MD, PhD Assistant Professor of Radiation Oncology Investigator, Center for Cancer Research Massachusetts General Hospital Harvard Medical School Boston, Massachusetts Kabir Mody, MD Associate Professor Department of Medicine, Division of

Hematology and Oncology Mayo Clinic Cancer Center Mayo Clinic Jacksonville, Florida

Dipika R. Mohan, PhD Fellow Medical Scientist Training Program

University of Michigan Ann Arbor, Michigan Michael Osborn, MBBS Lead Clinician Youth Cancer Service Royal Adelaide Hospital Adelaide, South Australia

Aviram Nissan, MD Professor of Surgery Head Department of General and Oncological Surgery—Surgery C Sheba Medical Center Ramat Gan, Israel Yves Pommier, MD, PhD Chief, Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology

Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, Maryland

† Fallecido/a.

xiii

AUTORES COLABORADORES

Alexander B. Olawaiye, MD Associate Professor Department of Obstetrics, Gynecology and Reproductive Sciences University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania Hima Bindu Musunuru, MBBS, MRCP, FRCR Department of Radiation Oncology The University of Pittsburgh Medical Center Pittsburgh, Pennsylvania Larissa Nekhlyudov, MD, MPH Professor Brigham and Women’s Hospital Harvard Medical School Boston, Massachusetts Andrea Ng, MD, MPH Professor of Radiation Oncology Department of Radiation Oncology Brigham and Women’s Hospital Dana-Farber Cancer Institute Harvard Medical School Boston, Massachusetts Quynh-Nhu Nguyen, MD, MHCM Professor Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston, Texas Mary Lynn Nierodzik, MD, FACP Clinical Assistant, Professor of Medicine Perlmutter Cancer Center Kyle R. Noll, PhD Assistant Professor Department of Neuro-Oncology The University of Texas MD Anderson Cancer Center Houston, Texas Ajay K. Nooka, MD MPH Associate Professor Department of Hematology Winship Cancer Institute of Emory University Atlanta, Georgia Dawn Owen, MD, PhD Associate Professor Department of Radiation Oncology Mayo Clinic Rochester, Minnesota Zachary R. Reichert, MD, PhD Clinical Assistant Professor Department of Internal Medicine, Division of Hematology and Oncology Rogel Cancer Center, University of Michigan Ann Arbor, Michigan NYU Langone Health New York, New York

Lee M. Ocuin, MD, FACS Assistant Professor of Surgery, Case Western Reserve University School of Medicine Department of Surgery, Division of Surgical Oncology University Hospitals Cleveland Medical Center Cleveland, Ohio Ciara C. O’Sullivan, MB, Bch, BAO Assistant Professor of Oncology Department of Medical Oncology Mayo Clinic Rochester, Minnesota

Michelle B. Riba, MD, MS Clinical Professor Department of Psychiatry University of Michigan Ann Arbor, Michigan

Tushar Patel, MBChB Dean for Research Mayo Clinic Jacksonville, Florida

Sachin Patil, MD General and Hepato-Pancreato-Biliary (HPB) Surgeon Department of General Surgery Ascension Providence Hospital Southfield, Michigan Anna C. Pavlick, MD, MBA Professor of Medicine and Dermatology Division of Medical Oncology Weill Cornell Medicine New York, New York Richard T. Penson, MD, MRCP Associate Professor of Medicine Harvard Medical School Clinical Director, Medical Gynecologic Oncology Massachusetts General Hospital Boston, Massachusetts Professor, Director, GI Program Department of Medical Oncology Thomas Jefferson University Philadelphia, Pennsylvania S. Vincent Rajkumar, MD Edward W. and Betty Knight Scripps Professor of Medicine Division of Hematology Mayo Clinic Rochester, Minnesota Jose Alejandro Rauh-Hain, MD, MPH Associate Professor Department of Gynecologic Oncology The University of Texas MD Anderson Cancer Center Houston, Texas Patrick M. Reagan, MD Assistant Professor Wilmot Cancer Institute University of Rochester Medical Center Rochester, New York Natasha Rekhtman, MD, PhD Thoracic Pathologist and Cytopathologist Department of Pathology Memorial Sloan Kettering Cancer Center New York, New York James A. Posey III, MD Doctorate of Medicine

Judith A. Paice, PhD, RN Director, Cancer Pain Program Department of Hematology- Oncology Feinberg School of Medicine, Northwestern University Chicago, Illinois

Ganesh S. Palapattu, MD, FACS, FRCS (Glasg) George F. and Sandy G. Valassis Professor and Chair of Urology

Department of Urology University of Michigan Ann Arbor, Michigan Henry S. Park, MD, MPH Assistant Professor Department of Therapeutic Radiology Yale School of Medicine New Haven, Connecticut

Katerina Politi, PhD Associate Professor Department of Pathology and Internal Medicine

Yale School of Medicine New Haven, Connecticut

Farhad Ravandi, MD Professor of Medicine Chief, Section of Acute Myeloid Leukemia Department of Leukemia The University of Texas MD Anderson Cancer Center Houston, Texas

Susan K. Parsons, MD, MRP Professor, Director of Cancer Survivorship Department of Medicine

Tufts Medical Center Boston, Massachusetts

Harvey I. Pass, MD Stephen A. Banner Professor of Thoracic Oncology Vice-Chairman, Research Department of Cardiothoracic Surgery NYU Langone Medical Center New York, New York

Lynn Ries, MS RiesSearch, LLC Rockville, Maryland

xiv

AUTORES COLABORADORES

Antoni Ribas, MD, PhD Professor

Arjun Sahgal, BSc, MD, FRCPC Professor of Radiation Oncology University of Toronto Deputy Chief, Department of Radiation Oncology Odette Cancer Centre Sunnybrook Health Sciences Centre Toronto, Ontario, Canada Leonard B. Saltz, MD Attending Physician and Member Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Wolfgang A.G. Sauerwein, MD, PhD Professor and Vice-Chair (retired) Department for Radiation Oncology and Radiotherapy University Hospital Essen Essen, Germany Sanne B. Schagen, PhD Clinical Neuropsychologist, Group Leader Department of Psychosocial Research and Epidemiology The Netherlands Cancer Institute Amsterdam, Netherlands Laura S. Schmidt, PhD Principal Scientist Basic Science Program SAIC-Frederick, Inc Frederick National Laboratory for Cancer Research Frederick, Maryland Urologic Oncology Branch, Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, Maryland Tarsheen Sethi, MD, MSCI Assistant Professor of Medicine Department of Medicine, Hematology Einat Shacham-Shmueli, MD Head of Gastrointestinal Cancer Unit Department of Oncology Sheba Medical Center, Affiliated with Sackler School of Medicine, Tel-Aviv University Ramat Gan, Israel Paul L. Swiecicki, MD Assistant Professor Department of Internal Medicine Division of Hematology and Oncology Kurt A. Schalper, MD, PhD Associate Professor Department of Pathology Yale School of Medicine New Haven, Connecticut Yale School of Medicine New Haven, Connecticut

Nirali N. Shah, MD, MHSc National Institutes of Health Lasker Clinical Research Scholar National Institutes of Health Distinguished Scholar Head, Hematologic Malignancies Section

Department of Medicine, Surgery, and Molecular and Medical Pharmacology University of California Los Angeles Los Angeles, California

Pediatric Oncology Branch National Cancer Institute National Institutes of Health Bethesda, Maryland

Andreas Rimner, MD Associate Attending

Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York Brian I. Rini, MD, FASCO Chief of Clinical Trials Department of Medicine, Division of Hematology and Oncology Vanderbilt Ingram Cancer Center Vanderbilt University Medical Center Nashville, Tennessee Robert Taylor Ripley, MD Associate Professor Department of Surgery, Division of

Alexander Stojadinovic, MD, MBA, MSc, FACS Senior Medical Director, Oncology Clinical Development—GSK Professor of Surgery (Hon) Colonel, United States Army, Medical Corps (Ret) Uniformed Services University of the Health Sciences (USUHS) alumnus Bethesda, Maryland Rory M. Shallis, MD Assistant Professor Section of Hematology, Department of Internal Medicine Vani N. Simmons, PhD Senior Member, Professor Department of Health Outcomes and Behavior H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida Yale School of Medicine New Haven, Connecticut

General Thoracic Surgery Baylor College of Medicine Houston, Texas Andrew L. Rosenberg, MD Chief Information Officer

University of Michigan Ann Arbor, Michigan

Steven A. Rosenberg, MD, PhD Chief, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Professor of Surgery, Uniformed Services University of the Health Sciences School of Medicine Bethesda, Maryland Professor of Surgery, George Washington University School of Medicine Washington, District of Columbia Kenneth Rosenzweig, MD Professor and Chairman Department of Radiation Oncology Icahn School of Medicine at Mount Sinai New York, New York Charles M. Rudin, MD, PhD Hassenfeld Professor and Chief, Thoracic Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Richard M. Simon, DSc R. Simon Consulting Potomac, Maryland

Samuel Singer, MD Director, The Sarcoma Center at Memorial Sloan Kettering Department of Surgery Memorial Sloan Kettering Cancer Center New York, New York

Jeffrey B. Smerage, MD, PhD Associate Professor Department of Internal Medicine, Division of Hematology and Oncology

University of Michigan Ann Arbor, Michigan

Fabienne Thomas, PharmD, PhD Assistant Professor of Pharmacology Faculté de Santé, Department de Pharmacie Institut Universitaire du Cancer de Toulouse—Oncopole Toulouse, France David B. Solit, MD Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Amber Rupe, PharmD Pharmacist Morrison Cancer Center Mary Lanning Healthcare Hastings, Nebraska

Bilal D. Shah, MD, MS Assistant Member Department of Malignant Hematology Moffitt Cancer Center Tampa, Florida

University of Michigan Ann Arbor, Michigan

xv

AUTORES COLABORADORES

Jeffrey A. Sosman, MD Professor of Medicine Robert H. Lurie Comprehensive Cancer Center of Northwestern University Chicago, Illinois James L. Speyer, MD Professor Emeritus of Medicine Perlmutter Cancer Center NYU Grossman School of Medicine New York, New York David Spiegel, MD Jack, Lulu, and Sam Willson Professor and Associate Chair Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine Stanford, California Department of Radiation Oncology University Hospitals Seidman Cancer Center Case Western Reserve University Cleveland, Ohio Stacey Stein, MD Associate Professor Department of Medical Oncology Daniel E. Spratt, MD Chairman

Hyuna Sung, PhD Principal Scientist Department of Surveillance and Health Equity Science American Cancer Society Atlanta, Georgia Nicholas J. Szerlip, MD Professor Department of Neurosurgery University of Michigan Ann Arbor, Michigan Mario Sznol, MD Professor Department of Internal Medicine (Medical Oncology)

Geoffrey B.Thompson, MD Chair, Emeritus Professor of Surgery Department of Surgery Sheikh Shakhbout Medical City, Mayo Clinic Mayo Clinic College of Medicine and Science Abu Dhabi, United Arab Emirates Anne Tsao, MD, MBA Vice President, Faculty and Academic Affairs Professor, Thoracic and Head and Neck Medical Oncology Clinical Medical Director, Thoracic and Orthopaedic Director, Mesothelioma Program The University of Texas MD Anderson Cancer Center Houston, Texas Christina Tsien, MD Professor The Johns Hopkins University School of Medicine Baltimore, Maryland

Yale School of Medicine New Haven, Connecticut

LynnT.Tanoue, MD, MBA Professor of Medicine Department of Internal Medicine

Yale School of Medicine New Haven, Connecticut

William D.Tap, MD Chief Attending, Sarcoma Medical Oncology AYA Co-Director Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Randall K.Ten Haken, PhD Professor Department of Radiation Oncology Kenneth D.Tew, PhD, DSc, FASPET Chairman Department of Pharmacology Medical University of South Carolina Charleston, South Carolina Krishnansu S.Tewari, MD, FACOG, FACS, FRSM Professor, The Philip J. DiSaia, MD Endowed Chair in Gynecologic Oncology Director Division of Gynecologic Oncology Department of Obstetrics and Gynecology University of California, Irvine Orange, California University of Michigan Ann Arbor, Michigan

Aaron M. Udager, MD, PhD Associate Professor Department of Pathology University of Michigan Ann Arbor, Michigan

Yale School of Medicine New Haven, Connecticut

Robert G. Uzzo, MD, MBA, FACS Interim CEO Chair, Department of Surgery Department of Urologic Oncology

Michael J. Strong, MD, PhD, MPH House Officer, PGY-5 Department of Neurosurgery

University of Michigan Ann Arbor, Michigan

Fox Chase Cancer Center Temple University School of Medicine Philadelphia, Pennsylvania

Roger Stupp, MD Co-Director, Malnati Brain Tumor Institute Robert H. Lurie Comprehensive Cancer Center Department of Neurological Surgery and Neurology Northwestern University Chicago, Illinois

John Austin Vargo, MD Assistant Professor Department of Radiation Oncology

University of Pittsburgh Pittsburgh, Pennsylvania

Karrie Anne Brondell Walker, DO Clinical REI Fellow National Institute of Child Health and Human Development Bethesda, Maryland Saiama N. Waqar, MBBS, MSCI Associate Professor of Medicine Department of Medical Oncology Washington University School of Medicine St. Louis, Missouri Jeffrey S. Weber, MD, PhD Deputy Director and Head, Experimental Therapeutics Laura and Isaac Perlmutter Cancer Center Professor of Medicine NYU Grossman School of Medicine New York, New York

Tanvi Subramanian, MD Department of Surgery University of Chicago Medicine Chicago, Illinois

Paul H. Sugarbaker, MD Director, Program in Peritoneal Surface Malignancy Washington Cancer Institute Washington, District of Columbia John H. Suh, MD Chairman Department of Radiation Oncology Taussig Cancer Institute Cleveland, Ohio Mark W.Youngblood, MD, PhD Department of Neurological Surgery Northwestern Memorial Hospital Chicago, Illinois

Anish Thomas, MD Investigator

Center for Cancer Research National Cancer Institute National Institutes of Health Bethesda, Maryland

Michael A. Vogelbaum, MD, PhD Professor, Program Leader of Neuro Oncology

Chief of Neurosurgery Moffit Cancer Center Tampa, Florida