9788419284495_Drilon.Oncología de bolsillo_3ed

First page 1 Next page Last page

Esta publicación interactiva se ha creado con FlippingBook, un servicio de streaming de archivos PDF en línea. Sin descargas ni esperas. ¡Solo necesita abrirlo y empezar a leer!

O ncología de bolsillo 3.ª Edición Editores Noura Choudhury Yonina R. Murciano-Goroff Asesores Alexander Drilon Neil Vasan Attending Physicians, Department of Medicine Memorial Sloan-Kettering Cancer Center SAMPLE

ONCOLOGÍA de bolsillo 3. a edición Editado por: N oura C houdhury , MD Assistant Attending,Thoracic Oncology & Early Drug Development Services Memorial Sloan Kettering Cancer Center New York, New York Y onina R. M urciano -G oroff , MS c , DP hil , MD SAMPLE Instructor, Early Drug Development Service Memorial Sloan Kettering Cancer Center New York, New York Asesores A lexander D rilon , MD Chief, Early Drug Development Service Memorial Sloan Kettering Cancer Center New York, New York N eil V asan , MD, P h D Assistant Attending Physician Breast Medicine Service Memorial Sloan Kettering Cancer Center New York, New York

Av. Carrilet, 3, 9. a planta, Edificio D - Ciutat de la Justícia 08902 L’Hospitalet de Llobregat, Barcelona (España) Tel.: 93 344 47 1 8 Fax: 93 344 47 1 6 e-mail: consultas@wolterskluwer.com Revisión científica Jaime G. de la Garza Salazar Investigador clínico del Instituto Nacional de Cancerología, México Paula Juárez Sánchez Patóloga oncóloga del Instituto Nacional de Cancerología, México Traducción Pedro Sánchez Rojas Médico cirujano por la Universidad Nacional Autónoma de México, México Armando Robles Hmilowicz Editor y traductor profesional, Doctores de Palabras, México

Dirección editorial: Carlos Mendoza Editora de desarrollo: Núria Llavina

Gerente de mercadotecnia: Pamela González Cuidado de la edición: Doctores de Palabras Adaptación de portada: Jesús Esteban Mendoza Impresión: Mercury Print Productions / Impreso en Estados Unidos

Se han adoptado las medidas oportunas para confirmar la exactitud de la informa ción presentada y describir la práctica más aceptada. No obstante, los autores, los redactores y el editor no son responsables de los errores u omisiones del texto ni de las consecuencias que se deriven de la aplicación de la información que incluye, y no dan ninguna garantía, explícita o implícita, sobre la actualidad, integridad o exactitud del contenido de la publicación. Esta publicación contiene información general relacionada con tratamientos y asistencia médica que no debería utilizarse en pacientes individuales sin antes contar con el consejo de un profesional médico, ya que los tratamientos clínicos que se describen no pueden considerarse recomendaciones absolutas y universales. El editor ha hecho todo lo posible para confirmar y respetar la procedencia del material que se reproduce en este libro y su copyright. En caso de error u omisión, se enmendará en cuanto sea posible. Algunos fármacos y productos sanitarios que se presentan en esta publicación solo tienen la aprobación de la Food and Drug Administration (FDA) para uso limitado al ámbito experimental. Compete al profesional sanitario averiguar la situación de cada fármaco o producto sanitario que pretenda utilizar en su práctica clínica, por lo que aconsejamos consultar con las autoridades sanitarias competentes. Derecho a la propiedad intelectual (C. P. Art. 270) Se considera delito reproducir, plagiar, distribuir o comunicar públicamente, en todo o en parte, con ánimo de lucro y en perjuicio de terceros, una obra literaria, artística o científica, o su transformación, interpretación o ejecución artística fijada en cualquier tipo de soporte o comunicada a través de cualquier medio, sin la autorización de los titulares de los correspondientes derechos de propiedad intelectual o de sus cesionarios. SAMPLE

Edición en español de la obra original en lengua inglesa Pocket Oncology 3. a edición, editada por Noura Choudhury y Yonina R. Murciano-Goroff y publicada por Wolters Kluwer Copyright © 2023 Wolters Kluwer

Two Commerce Square 200 1 Market Street Philadelphia, PA 1 9 1 03 ISBN de la edición original: 978- 1 -975 1 -908 1 - 1

Dedicamos este manual a nuestros pacientes, cuyo valor inquebrantable ante la adversidad nos inspira a ser mejores médicos y seres humanos.

SAMPLE

CONTENIDO

Colaboradores

Prólogo Prefacio

xxviii

xxix

ONCOLOGÍA GENERAL

1 - 1

Julian A.Waksal, Binbin Zheng-Lin,Victoria Blinder, Samuel Freedman, Jodi Mones Epidemiología del cáncer

1 - 1 1 -3 1 -5

Prevención y detección del cáncer

Teleoncología

MÉTODOS DE INVESTIGACIÓN CLÍNICA 2-6 Sandeep S. Raj, Alison Schram, Robert Stuver, Martin H.Voss, Xiaodi Wu, Ayca Gucalp, Andrew Vickers, Noura Choudhury, Gregory J. Riely Ensayos clínicos de fase I 2-6 Ensayos clínicos de fase II y III 2-8 Desarrollo de biomarcadores 2- 1 0 Aspectos regulatorios de ensayos clínicos 2- 1 3 RADIOONCOLOGÍA 3- 1 5 Emily S. Lebow, Daniel Gomez, Barry S. Rosenstein, N. Ari Wijetunga, Simon N. Powell, Christopher H. Crane, Patricia Mae G. Santos, Neil K.Taunk, Michael J. Zelefsky, Brandon S. Imber,

Daniel S. Higginson,Yoshiya (Josh) Yamada Biología y física básicas de la radiación

3- 1 5 3- 1 7 3- 1 9 3-2 1 3-23 3-25

Radioterapia externa

Radioterapia estereotáctica

Braquiterapia ICT y TTPHE

Urgencias de radiooncología

PRINCIPIOS DE CIRUGÍA Y ONCOLOGÍA INTERVENCIONISTA Jay S. Lee, Michael I. D’Angelica, Alice Chia-chi Wei,Vibhor Wadhwa, Ernesto Santos, Etay Ziv, An Thi Nhat Ho,Varun Shah, Robert P. Lee, Mohit Chawla Principios de oncología quirúrgica 4-28 Urgencias quirúrgicas 4-29 Neumología intervencionista 4-3 1 Introducción a la radiología intervencionista 4-34 Terapias transarteriales 4-35 Ablación percutánea guiada por imagen 4-36 Intervenciones musculoesqueléticas 4-37 Urgencias de radiología intervencionista 4-38 BIOLOGÍA DEL CÁNCER 5-40 Lauren Baker Banks, Juan C. Osorio, Ezra Rosen,Yonit Lavin, Karuna Ganesh, Jessie Bourcier, Michelangelo Marasco, Rona Yaeger, Varun Narendra, Benjamin Alexander Nacev, Benjamin Herzberg Cáncer y células madre: rasgos distintivos 5-40 5-4 1 Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE 4-28 Mecanismos de oncogénesis

Señalización de los factores de crecimiento

5-42 5-43 5-44 5-45

Control del ciclo celular

Transcripción, apoptosis y TP53 Reparación de ADN y angiogénesis DIAGNÓSTICO MOLECULAR

6-46

Tony El Jabbour, Omar Abdel-Wahab, Abhinita S. Mohanty, Jason E. Chan, Sydney X. Lu, Ryma Benayed Secuenciación

6-46 6-47 6-49

Citogenética

Secuenciación de ARN

INMUNOLOGÍA DEL CÁNCER

7-50

Juan C. Osorio, Lauren Baker Banks, Alexander M. Lesokhin, David Knorr, Christopher A. Klebanoff, Susan Ehrenkranz De Wolf, Michael Postow, Adam J. Schoenfeld Inmunobiología del cáncer

7-50 7-52 7-53 7-55 7-57 7-58

Terapia de anticuerpos inmunorreguladores

Toxicidad de los inhibidores de puntos de control inmunitario

Inmunoterapias

Terapia con linfocitos T-CAR

Linfocitos infiltrantes de tumores (LIT) GENÉTICA DEL CÁNCER

8-59

Viswatej Avutu, Zsofia K. Stadler, Kelsey Breen Síndromes hereditarios de cáncer y cánceres hereditarios de mama y ovario: fundamentos 8-59 Síndrome de Lynch 8-6 1 Poliposis adenomatosa familiar (PAF) 8-62 Síndrome de Li-Fraumeni 8-63 Otros síndromes genéticos 8-64 FARMACOLOGÍA DEL CÁNCER 9-66 Amber C. King, Josiah D. Land, Dazhi Liu,Tim Peterson, Samantha N. Reiss, Grashma Vadakkel, Stephen Eng,Terry Pak, Nicole Daukshus, Krisoula H. Spatz, Andréa LeVoir, Michael J. Buege,Taylor M.Weis, Jillian Gutierrez Farmacogenética y farmacogenómica 9-66 Conjugado anticuerpo-fármaco 9-68 Anticuerpos monoclonales 9-70 Antimetabolitos 9-75 Fármacos alquilantes 9-79 Fármacos antimicrotúbulos 9-84 Antibióticos antitumorales 9-86 Inhibidores de la topoisomerasa 9-88 Inmunomoduladores/modificadores epigenéticos 9-90 Inhibidores de la vía de moléculas pequeñas 9-93 Fármacos hormonales 9- 1 07 Fármacos modificadores del hueso 9- 111 Nuevos anticoagulantes orales (NACO) 9- 11 3 Tratamiento con factores de crecimiento 9- 11 5 Fármacos diversos 9- 11 6 Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

COMPLICACIONES DEL CÁNCER Duaa H. Al-Rawi, Mark Blaine Geyer,Tarik Al-Bermani, Julian A.Waksal, Kelly N. Fitzgerald, Maya Viavant, Jennifer Ma Síndrome de lisis tumoral

1 0- 11 9

1 0- 11 9 1 0- 1 2 1 1 0- 1 23 1 0- 1 25 1 0- 1 27

Urgencias metabólicas Síndrome de la VCS

Compresión de la médula espinal Consejos para becarios de guardia

CUIDADOS PALIATIVOS Y DE APOYO

11 - 1 28

Jennifer A. Salant, Stacy Stabler, Ramy Sedhom, Anjali Varma Desai, Hyeyoung Erin Jeun, Natalie Moryl, Samantha Francis, Andreana Kwon, Karan Jatwani, Reggie T. Saldivar,Viswatej Avutu, Katherine Thornton, Andrew D. Hunter, Armin Shahrokni, Shilpa S. Lad, Martin S. Chin Cuidados paliativos: fundamentos 11 - 1 28 Medicamentos para el dolor 11 - 1 30 Tratamiento de síntomas no dolorosos 11 - 1 32 Obstrucción intestinal maligna y APT 11 - 1 35 Oncología de adolescentes y adultos jóvenes 11 - 1 37 Oncología del adulto mayor 11 - 1 38 Psicooncología 11 - 1 39 SUPERVIVENCIA AL CÁNCER Y PRESERVACIÓN DE LA FERTILIDAD 1 2- 1 4 1 Lauren Martino, Jennifer Gorelov, Matthew Matasar Supervivencia al cáncer 1 2- 1 4 1 Preservación de la fertilidad 1 2- 1 44 ENFERMEDADES INFECCIOSAS 1 3- 1 46 Mario D. Caldararo, Marilia Bernardes, Monika K. Shah, Cesar J. Figueroa Ortiz Paciente oncológico de alto riesgo 1 3- 1 46 Infecciones en receptor de trasplante 1 3- 1 49 COVID- 1 9 y cáncer 1 3- 1 5 1 ENFERMEDADES MALIGNAS GU 1 4- 1 52 Niamh M. Keegan, Maria Carlo, Howard I. Scher, Brendan J. Guercio, Samuel A. Funt, Kelly N. Fitzgerald, Chung-Han Lee, Michael Lattanzi, Dean Bajorin Cáncer de próstata localizado 1 4- 1 52 Cáncer de próstata recidivado/metastásico 1 4- 1 54 Cáncer de vejiga urinaria 1 4- 1 56 Carcinoma de células renales 1 4- 1 58 Tumor de células germinales 1 4- 1 6 1 Cáncer de pene 1 4- 1 63 ENFERMEDADES MALIGNAS TORÁCICAS 1 5- 1 64 Jia Luo, Mark G. Kris, Philip Choi,W.Victoria Lai, Noura Choudhury, Gregory J. Riely, Michael Offin, Marjorie G. Zauderer Cáncer de pulmón no microcítico 1 5- 1 64 Cáncer de pulmón microcítico 1 5- 1 67 Timoma y carcinoma tímico 1 5- 1 69 Mesotelioma pleural maligno 1 5- 1 7 1 Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

ENFERMEDADES MALIGNAS GI Dan Feng, Leonard Saltz, Ghassan K. Abou-Alfa, Samyukta Mullangi, Eileen M. O’Reilly, Joshua D. Schoenfeld, Michael B. Foote, Nitya Raj, Diane Reidy-Lagunes, Ryan Moy,Yelena Y. Janjigian, Melissa Amy Lumish, Andrea Cercek, Salvador Alonso Martinez, Neil H. Segal,Yonit Lavin, Anna M.Varghese Carcinoma hepatocelular (CHC)

1 6- 1 73

1 6- 1 73 1 6- 1 75 1 6- 1 77 1 6- 1 79 1 6- 1 8 1 1 6- 1 83 1 6- 1 86 1 6- 1 87 1 6- 1 89 1 6- 1 9 1 1 6- 1 93

Cáncer del árbol biliar Cáncer de páncreas

Neoplasias neuroendocrinas pancreáticas y GI

Cáncer de esófago Cáncer de estómago

Carcinoma de apéndice e intestino delgado

Cáncer de colon Cáncer de recto Cáncer de ano

Cáncer de sitio primario desconocido (CPD)

CÁNCERES DE PIEL Y SARCOMAS Ryan Q. Notti,William D.Tap, Jonathan Kentley, Allan Halpern, James W. Smithy, Paul Chapman Carcinoma basocelular y escamocelular

1 7- 1 95

1 7- 1 95 1 7- 1 97 1 7- 1 99 1 7-20 1 1 7-203 1 7-205

Melanoma

Sarcomas de tejidos blandos (STB) Tumor del estroma gastrointestinal

Sarcomas óseos

Tumores de la familia del sarcoma de Ewing (TFSE)

ENF MALIGNAS DE CABEZA Y CUELLO Bharat Burman, Lara Dunn, Anupriya Singhal, Alan L. Ho Cáncer escamocelular de cabeza y cuello

1 8-207

1 8-207 1 8-209 1 8-2 1 0

Carcinoma nasofaríngeo

Tumores de glándulas salivales SAMPLE ENF MALIGNAS ENDOCRINAS Duaa H. Al-Rawi, Laura Boucai, Eliza B. Geer, Priya Jaisinghani, Binbin Zheng-Lin, Sapir Nachum Cáncer de tiroides 1 9-2 11 1 9-2 11 1 9-2 1 3 1 9-2 1 6 1 9-2 1 9 Tumores de la silla turca Feocromocitomas y síndrome MEN Tumores de la corteza suprarrenal

ENF MALIGNAS GINECOLÓGICAS Melissa Amy Lumish, Maria Rubinstein, Duaa H. Al-Rawi, Olga T. Filippova, Roisin E. O’Cearbhail, Sushmita Gordhandas, Rachel N. Grisham,William A. Zammarrelli III, Lea A. Moukarzel, William P.Tew Cáncer de ovario

20-22 1

20-22 1 20-223 20-225

Tumor de células germinales de ovario

Carcinoma de endometrio

Cáncer de cuello uterino Cáncer de vulva y vagina CÁNCER DE MAMA

20-229 20-23 1

2 1 -233

Anton Safonov, Devika Gajria, Emanuela Ferraro,Tiffany A.Traina, Joshua Z. Drago, Chau Dang Cáncer de mama: introducción

2 1 -233 2 1 -235 2 1 -237

Cáncer de mama localizado Cáncer de mama metastásico

ONCOLOGÍA NEUROLÓGICA Elizabeth Anne Coffee, Kevin B. Elmore, Maria Diaz, Thomas J. Kaley, Jessica A.Wilcox Glioma de bajo grado

22-239

22-239 22-24 1 22-243 22-245

Glioma de alto grado

Enfermedad metastásica del SNC

Síndromes paraneoplásicos

LINFOMAS

23-247

Alexander P. Boardman, Robert Stuver, Santosha A.Vardhana, Alison Moskowitz, Beatriz Wills, Gilles Salles, David Qualls, Ariela Noy, Robert Stuver, Anita Kumar, Zachary Epstein-Peterson, Erel Joffe, Steven Horwitz, Christian Grommes Linfoma de Hodgkin

23-247 23-249 23-25 1 23-253 23-255 23-257 23-259 23-26 1

Linfoma folicular

Linfoma de la zona marginal Linfoma de células del manto

Linfoma difuso de linfocitos B grandes

Linfoma de Burkitt

Linfoma periférico de linfocitos T Linfoma de linfocitos T cutáneo

Linfoma primario del SNC 23-263 TRASTORNOS DE LAS CÉLULAS PLASMÁTICAS 24-265 Xiaodi Wu, Malin Hultcrantz, Robert Stanley, Kylee Maclachlan, Sandeep S. Raj, M. Lia Palomba, Heather Landau GMSI y mieloma múltiple (MM) 24-265 Macroglobulinemia de Waldenström 24-270 Amiloidosis 24-272 TRASTORNOS MIELOPROLIFERATIVOS 25-274 Maximilian Stahl,Varun Narendra, Martin S.Tallman, Michael J. Mauro, Aaron James Stonestrom, Raajit K. Rampal Trombocitemia esencial (TE) 25-274 Policitemia vera 25-276 Mielofibrosis 25-278 Mastocitosis/síndrome hipereosinofílico 25-280 SAMPLE

LEUCEMIAS Y SÍND MIELODISPLÁSICOS 26-282 Maximilian Stahl,Varun Narendra, Martin S.Tallman, Omar Abdel-Wahab, Aaron D. Goldberg, Susan Ehrenkranz De Wolf, Jae H. Park, Mark Blaine Geyer, Michael J. Mauro, Meghan C.Thompson, Anthony Rocco Mato, Aaron James Stonestrom, Ross Levine Síndromes mielodisplásicos 26-282 Leucemia mielógena aguda (LMA) 26-284 Leucemias/linfomas linfoblásticos agudos 26-288 Leucemia mielógena crónica (LMC) 26-290 Leucemia linfocítica crónica (LLC) 26-292 Leucemia de células pilosas y prolinfocítica 26-295 Hematopoyesis clonal (HC) 26-297 TRASPLANTE DE CÉLULAS MADRE 27-298 Mariam T. Nawas, Michael Scordo, Christina Cho Trasplante autólogo de células madre 27-298 Trasplante alogénico de células madre 27-300 HEMATOLOGÍA BENIGNA 28-303 Simon Mantha, Meghan C.Thompson, Ioannis Politikos, Jodi Mones, Robert Stuver, Melody Smith, Zachary Epstein-Peterson, Cy R.Wilkins, Alexandra Budhai, Maly Fenelus Biología de la hematopoyesis 28-303 Anemias por baja producción 28-305 Anemias hemolíticas 28-307 Hemoglobinopatías 28-3 1 0 Estados hipercoagulables 28-3 1 2 Porfirias 28-3 1 4 Diátesis hemorrágicas 28-3 1 5 Trastornos plaquetarios 28-3 1 8 Medicina transfusional 28-32 1 Pruebas de cribado en hemostasia 28-323 CÁNCERES PEDIÁTRICOS 29-326 Christina Fong, Allyson Flower, Alexandre G.Troullioud Lucas, Jaclyn Rosenzweig, Maria Luisa Sulis, Sheila S. McThenia, Sameer Farouk Sait, Morgan Pines, Michael Kinnaman, Carly Rosemore, Emily K. Slotkin, Jessica Stiefel, Fiorella Iglesias Cardenas, Melanie Degliuomini, Michael V. Ortiz, Ira J. Dunkel, Zahra Hudda, Julia Glade Bender, Madhavi Lakkaraja, María I. Cancio, Sanam Shahid, Barbara Spitzer Consideraciones pediátricas generales 29-326 Urgencias oncológicas pediátricas 29-328 Tumores hemáticos pediátricos 29-330 Síndromes de insuficiencia de médula ósea 29-334 Trasplante y terapia celular 29-337 Tumores malignos del SNC 29-340 Tumores óseos malignos 29-343 SAMPLE Beatriz Wills, Mariam T. Nawas, Rekha Paramesawaran, Varun Narendra, Sheng F. Cai, Aaron James Stonestrom,

Sarcoma de tejidos blandos

29-344 29-345 29-347 29-349 29-350

Neuroblastoma (NB)

Tumores hepáticos y renales

Retinoblastoma (RB)

Tumor de células germinales

FOTOGRAFÍAS A COLOR

35 1

Peter Maslak, Alyce M. Kuo, Mario Lacouture Frotis de sangre periférica y aspirados/biopsias de médula ósea Efectos adversos cutáneos de los tratamientos contra el cáncer

35 1 359

APÉNDICES

367

Matthew R. Kudelka,Yonina R. Murciano-Goroff, Michael Postow, Yugandhara Kate, Stacy Stabler, Anna M.Varghese, Scott Millman Puntuación del desempeño

367 368 369 37 1 373

Criterios de respuesta radiográfica Evaluación de la calidad de vida

Marcadores tumorales

Pasos de biopsia/aspirado de MO

SIGLARIO

374 388

ÍNDICE ALFABÉTICO DE MATERIAS

SAMPLE

COLABORADORES

EDITORES DE SECCIÓN

Omar Abdel-Wahab, MD Director, MSK Center for Hematologic Malignancies Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Duaa H. Al-Rawi, MD, PhD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center Manhattan, New York Viswatej Avutu, MD Assistant Attending Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Lauren Baker Banks, MD, PhD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Marilia Bernardes, MD Fellow, Infectious Diseases Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Alexander P. Boardman, MD Fellow, Hematology and Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Laura Boucai, MD Associate Professor of Medicine, Endocrinology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Bharat Burman, MD, PhD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Mario D. Caldararo, MD, MS Fellow, Infectious Diseases Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Maria Carlo, MD Assistant Attending Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Elizabeth Anne Coffee, MD Fellow, Neuro-Oncology Department of Neurology Memorial Sloan Kettering Cancer Center

New York, New York Maria Diaz, MD

Fellow, Neuro-Oncology Department of Neurology Memorial Sloan Kettering Cancer Center New York, New York Lara Dunn, MD Assistant Attending Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Kevin B. Elmore, MD Fellow, Neuro-Oncology Department of Neurology Memorial Sloan Kettering Cancer Center New York, New York SAMPLE

Daniel Gomez, MD, MBA Director,Thoracic Radiation Oncology Vice Chair of Clinical Operations, Department of Radiation Oncology Memorial Sloan Kettering Cancer Care Center New York, New York Jennifer Gorelov, AGNP-BC, MSN, OCN Nurse Practitioner Nursing Memorial Sloan Kettering Cancer Center New York, New York Yonina R. Murciano-Goroff, MSc, DPhil, MD Instructor, Early Drug Development Service Memorial Sloan Kettering Cancer Center New York, New York An Thi Nhat Ho, MD Fellow, Interventional Pulmonary Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Malin Hultcrantz, MD, PhD Attending Physician Myeloma Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Tony El Jabbour, MD Fellow, Molecular Genetic Pathology Department of Pathology Memorial Sloan Kettering Cancer Center New York, New York Niamh M. Keegan, MB, BCH, BAO

Dan Feng, MD, PhD Fellow, Hematology and Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Cesar J. Figueroa Ortiz, MD, MPH Infectious Diseases Attending Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Allyson Flower, MD Assistant Attending Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Christina Fong, MD Fellow, Pediatric Hematology/ Oncology Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Devika Gajria, MD, MPH Attending Physician Breast Medicine Service Memorial Sloan Kettering Cancer Center New York, New York Eliza B. Geer, MD Medical Director, Multidisciplinary Pituitary and Skull Base Tumor Center Department of Medicine and Neurosurgery Memorial Sloan Kettering Cancer Center New York, New York Mark Blaine Geyer, MD Assistant Attending Leukemia Service and Cell Therapy Service Department of Medicine Memorial Sloan-Kettering Cancer Center New York, New York

Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Melissa Amy Lumish, MD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Jia Luo, MD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Lauren Martino, MSN, RN Fertility Nurse Specialist Memorial Sloan Kettering Cancer Center New York, New York Matthew Matasar, MD, MS Director, MSK Bergen Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York & Montvale, New Jersey Varun Narendra, MD, PhD Fellow, Hematology and Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Mariam T. Nawas, MD Chief Fellow, Hematology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Ryan Q. Notti, MD, PhD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Amber C. King, PharmD, BCOP Clinical Pharmacy Specialist III Pharmacy, Clinical Programs Memorial Sloan Kettering Cancer Center New York, New York Mark G. Kris, MD Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Matthew R. Kudelka, MD, PhD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Josiah D. Land, PharmD, BCOP Clinical Pharmacy Specialist Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York Emily S. Lebow, MD Resident Physician Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York Jay S. Lee, MD Fellow, Complex General Surgical Oncology Department of Surgery Memorial Sloan Kettering Cancer Center New York, New York Alexander M. Lesokhin, MD Associate Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Juan C. Osorio, MD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Rekha Parameswaran, MD Attending Hematology Service Memorial Sloan Kettering Cancer Center New York, New York Sandeep S. Raj, MD Fellow, Hematology and Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Ezra Rosen, MD, PhD Assistant Professor of Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Maria Rubinstein, MD Assistant Attending, Gynecologic Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Anton Safonov, MD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Jennifer A. Salant, MD Director, Pediatric Advanced Care Team Department of Pediatrics Weill Cornell Medicine Fellow, Hospice and Palliative Medicine Memorial Sloan Kettering Cancer Center New York, New York Leonard Saltz, MD Attending Physician and Member Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Alison Schram, MD Assistant Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Michael Scordo, MD Assistant Attending, Adult Bone Marrow Transplant Service, Cellular Therapy Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Monika K. Shah, MD Deputy Physician-in-Chief, Education and Faculty Affairs Memorial Sloan Kettering Cancer Center New York, New York Stacy Stabler, MD, PhD Associate Attending, Supportive Care Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Zsofia K. Stadler, MD Clinic Director, Clinical Genetics Service Gastrointestinal Oncology, Associate Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Maximilian Stahl, MD Chief Fellow, Hematology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Robert Stuver, MD Fellow, Medical Oncology and Hematology Lymphoma Division Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Martin S. Tallman, MD Chief, Leukemia Service Memorial Sloan Kettering Cancer Center New York, New York William D. Tap, MD Chief, Sarcoma Medical Oncology Service Co-Director of AYA Program Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Santosha A. Vardhana, MD, PhD Assistant Professor Medicine, Lymphoma Service Memorial Sloan Kettering Cancer Center New York, New York Vibhor Wadhwa, MD Fellow, Interventional Radiology Department of Radiology Weill Cornell Medical Center Memorial Sloan Kettering Cancer Center New York, New York Ghassan K. Abou-Alfa, MD, MBA Professor Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Tarik Al-Bermani, MD Chief Resident Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Dean Bajorin, MD, FACP Attending Physician and Member, Memorial Hospital Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Julian A. Waksal, MD Chief Resident Department of Medicine Memorial Sloan Kettering Cancer Center Chief Fellow, Hematology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Xiaodi Wu, MD, PhD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York New York, New York Beatriz Wills, MD

AUTORES COLABORADORES

Ryma Benayed, MS, PhD Associate Attending Department of Pathology Memorial Sloan Kettering Cancer Center New York, New York Julia Glade Bender, MD Vice Chair for Clinical Research; Member, Memorial Hospital Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Victoria Blinder, MD, MSc Associate Attending Department of Psychiatry Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Jessie Bourcier, MD Research Fellow Omar Abdel-Wahab Lab—Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York, New York Kelsey Breen, MS, MSc Senior Genetic Counselor Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Alexandra Budhai, MD Attending Physician Laboratory Medicine Memorial Sloan Kettering Cancer Center New York, New York Michael J. Buege, PharmD Clinical Pharmacy Specialist Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York Sheng F. Cai, MD, PhD Assistant Attending Department of Medicine, Leukemia Service Memorial Sloan Kettering Cancer Center New York, New York María I. Cancio, MD Assistant Professor Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Fiorella Iglesias Cardenas, MD, MS Assistant Attending Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Jason E. Chan, MD, PhD Instructor, Sarcoma Medical Oncology Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Paul Chapman, MD Attending Physician, Melanoma Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Mohit Chawla, MD, FCCP Chief Pulmonary Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Martin. S. Chin, MD Attending Psychiatrist Department of Psychiatry and Behavioral Sciences Memorial Sloan Kettering Cancer Center New York, New York Christina Cho, MD Assistant Attending Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Philip Choi, MD, PhD Fellow, Medical Oncology and Hematology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE Andrea Cercek, MD Associate Attending Physician Department of Gastrointestinal Oncology Memorial Sloan Kettering Cancer Center New York, New York

Anjali Varma Desai, MD, MSCE Attending Physician, Supportive Care and Hospital Medicine Services Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Joshua Z. Drago, MD Assistant Attending Physician Breast Medicine Service Memorial Sloan Kettering Cancer Center New York, New York Ira J. Dunkel, MD Attending Pediatric Oncologist Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Stephen Eng, PharmD, BCOP Bone Marrow Transplant Clinical Pharmacy Specialist Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York Zachary Epstein-Peterson, MD Assistant Attending Department of Medicine Lymphoma Service, Division of Hematologic Malignancies Memorial Sloan Kettering Cancer Center New York, New York Maly Fenelus, MD, MPH Medical Director, Clinical Hemostasis and Coagulation Laboratory Laboratory Medicine Memorial Sloan Kettering Cancer Center New York, New York Emanuela Ferraro, MD

Noura Choudhury, MD Assistant Attending,Thoracic Oncology & Early Drug Development Services Memorial Sloan Kettering Cancer Center New York, New York Christopher H. Crane, MD Attending Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York Michael I. D’Angelica, MD, FACS Attending, Department of Surgery Director, Hepatopancreatobiliary Fellowship Program Director, Surgical Oncology Fellowship Program Vice Chair, Education Memorial Sloan Kettering Cancer Center New York, New York Chau Dang, MD Medical Director Department of Medicine Memorial Sloan Kettering Cancer Center West Harrison, New York Nicole Daukshus, PharmD Pediatric Hematology/Oncology Clinical Pharmacy Specialist Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York Susan Ehrenkranz De Wolf, MD Instructor Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Melanie Degliuomini, MD Fellow Physician Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York

Fellow, Clinical Research Breast Medicine Service Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Aaron D. Goldberg, MD, PhD Assistant Attending Physician Leukemia Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Sushmita Gordhandas, MD Fellow, Gynecologic Oncology Department of Surgery Memorial Sloan Kettering Cancer Center New York, New York Rachel N. Grisham, MD Associate Attending, Gynecologic Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Christian Grommes, MD Attending Physician Department of Neurology Memorial Sloan Kettering Cancer Center New York, New York Ayca Gucalp, MD Assistant Attending Physician Breast Medicine Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Olga T. Filippova, MD, MSc Fellow, Gynecology Service Department of Surgery Memorial Sloan Kettering Cancer Center New York, New York Kelly N. Fitzgerald, MD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Michael B. Foote, MD Fellow, Medical Oncology and Hematology Memorial Sloan Kettering Cancer Center New York, New York Samantha Francis, MD Assistant Attending Medicine/Supportive Care Memorial Sloan Kettering Cancer Center New York, New York Samuel Freedman, MD Assistant Attending Hospital Medicine Memorial Sloan Kettering Cancer Center New York, New York Samuel A. Funt, MD Assistant Attending Department of Medicine, Division of Genitourinary Oncology Memorial Sloan Kettering Cancer Center New York, New York Karuna Ganesh, MD, PhD Assistant Member and Attending Physician Molecular Pharmacology Program, Sloan Kettering Institute and Gastrointestinal Oncology Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Brendan J. Guercio, MD Fellow, Hematology-Oncology Memorial Sloan Kettering Cancer Center New York, New York Jillian Gutierrez, PharmD, BCOP Bone Marrow Transplant Clinical Pharmacy Specialist Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Allan Halpern, MD, MSc Chief Dermatology Service Associate Vice Chairman Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Benjamin Herzberg, MD Chief Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Daniel S. Higginson, MD Assistant Member Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York Alan L. Ho, MD, PhD Associate Member Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Steven Horwitz, MD Member and Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Zahra Hudda, MD Fellow, Pediatric Hematology Oncology Memorial Sloan Kettering Cancer Center New York, New York Andrew D. Hunter, MD/ MPH Fellow, Hospice and Pallative Medicine Memorial Sloan Kettering Cancer Center New York, New York

Brandon S. Imber, MD, MA Assistant Attending Radiation Oncologist Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York Priya Jaisinghani, MD Fellow, Endocrinology Endocrinology, Diabetes & Metabolism/Internal Medicine New York Presbyterian-Weill Cornell Memorial Sloan Kettering Cancer Center New York, New York Yelena Y. Janjigian, MD Associate Professor and Chief of Gastrointestinal Oncology Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Karan Jatwani, MBBS, MD Fellow, Hospice and Palliative Medicine Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Hyeyoung Erin Jeun, MD Fellow, Hospice and Palliative Medicine Memorial Sloan Kettering Cancer Center New York, New York

Erel Joffe, MD Assistant Attending Lymphoma Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Thomas J. Kaley, MD Associate Attending Department of Neurology Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Yugandhara Kate, MD Fellow, Hospice and Palliative Medicine Memorial Sloan Kettering Cancer Center New York, New York Jonathan Kentley, MBBS, MSC, MRCP (UK) Research Associate Department of Dermatology Memorial Sloan Kettering Cancer Center New York, New York Michael Kinnaman, MD Instructor Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Christopher A. Klebanoff, MD Assistant Member and Attending Physician Human Oncology and Pathogenesis Program, Immuno-Oncology Section Memorial Sloan Kettering Cancer Center New York, New York David Knorr, MD, PhD, MSc Assistant Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Anita Kumar, MD Assistant Attending, Medical Site Director Department of Medical Oncology Memorial Sloan Kettering Cancer Center New York, New York & Basking Ridge, New Jersey Alyce M. Kuo, BS Medical Student Dermatology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Andreana Kwon, MD Assistant Attending, Clinical Professor Department of Medicine, Department of Emergency Medicine Memorial Sloan Kettering Cancer Center New York, New York Mario Lacouture, MD Director, Oncodermatology Department of Dermatology Memorial Sloan Kettering Cancer Center New York, New York Shilpa S. Lad, MD, MS Fellow, Psycho-Oncology Department of Psychiatry Memorial Sloan Kettering Cancer Center New York, New York W. Victoria Lai, MD Assistant Professor Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Madhavi Lakkaraja, MD, MPH Fellow, Pediatric Hematology Oncology Memorial Sloan Kettering Cancer Center New York, New York Heather Landau, MD, PhD Assistant Professor Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Michael Lattanzi, MD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Yonit Lavin, MD, PhD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Chung-Han Lee, MD, PhD Assistant Attending Physician Department of Medicine Genitourinary Oncology Service Memorial Sloan Kettering Cancer Center New York, New York Robert P. Lee, MD Section Head, Section of Interventional Pulmonology Pulmonary Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Ross Levine, MD Chief, Molecular Cancer Medicine Service Human Oncology Pathogenesis Program Memorial Sloan Kettering Cancer Center New York, New York Andréa LeVoir, PharmD Clinical Pharmacy Specialist, Lymphoma Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York Dazhi Liu, PharmD, BCOP Clinical Pharmacy Specialist Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York Sydney X. Lu, MD, PhD Assistant Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Jennifer Ma, MD Radiation Oncology Resident Physician Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York

Kylee Maclachlan, BSc, MBChB, PhD Postdoctoral Researcher Memorial Sloan Kettering Cancer Center New York, New York Simon Mantha, MD, MPH Attending Physician Hematology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Michelangelo Marasco, MD, PhD Research Scholar Molecular Pharmacology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center New York, New York Salvador Alonso Martinez, MD Clinical Fellow Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Peter Maslak, MD Chief, Immunology Laboratory Service Pathology and Laboratory Medicine Memorial Sloan Kettering Cancer Center New York, New York Anthony Rocco Mato, MD Director, CLL Program Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Michael J. Mauro, MD Leader, Myeloproliferative Neoplasms Program Leukemia Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Ryan Moy, MD, PhD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Samyukta Mullangi, MD, MBA Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Sapir Nachum, MD Resident Physician Memorial Sloan Kettering Cancer Center New York, New York Benjamin Alexander Nacev, MD, PhD Assistant Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Ariela Noy, MD Attending Physician, Lymphoma Service Memorial Sloan Kettering Cancer Center New York, New York Roisin E. O’Cearbhaill, MD Medical Oncologist Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Michael Offin, MD Assistant Attending,Thoracic Oncology Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

Sheila S. McThenia, MD Fellow, Pediatric Hematoloy Oncology Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Scott Millman, MD, PhD Instructor, Leukemia Service Memorial Sloan Kettering Cancer Center New York, New York Abhinita S. Mohanty, MS Senior Computational Biologist I Department of Pathology Memorial Sloan Kettering Cancer Centre New York, New York Jodi Mones, MD Associate Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Natalie Moryl, MD Attending Addiction, Hospice and Palliative Care Supportive Care Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Alison Moskowitz, MD Associate Attending Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Lea A. Moukarzel, MD Fellow Department of Surgery, Gynecology Memorial Sloan Kettering Cancer Center New York, New York

SAMPLE

Eileen M. O’Reilly, MD Attending Physician, Professor of Medicine Department of Medicine, Gastrointestinal Oncology Service Memorial Sloan Kettering Cancer Center New York, New York Michael V. Ortiz, MD Assistant Attending Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Terry Pak, PharmD Pharmacist Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York M. Lia Palomba, MD Member and Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Jae H. Park, MD Associate Attending Physician Department of Medicine, Leukemia Service & Cellular Therapeutics Service Memorial Sloan Kettering Cancer Center New York, New York Tim Peterson, PharmD, BCOP Clinical Pharmacy Specialist Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York Morgan Pines, MD Fellow, Pediatric Hematology Oncology Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York

Ioannis Politikos, MD Assistant Attending Adult Bone Marrow Transplant Service Memorial Sloan-Kettering Cancer Center New York, New York Michael Postow, MD Chief, Melanoma Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Simon N. Powell, MD, PhD Chair Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York David Qualls, MD Fellow, Hematology and Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Nitya Raj, MD Assistant Attending Physician Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Raajit K. Rampal, MD, PhD Associate Member Leukemia Service Memorial Sloan Kettering Cancer Center New York, New York Diane Reidy-Lagunes, BS, MS, MD Oncologist Department of Medicine Associate Deputy Physician-in Chief, Regional Care Network President, MSK Medical Staff Memorial Sloan Kettering Cancer Center New York, New York

SAMPLE

Samantha N. Reiss, PharmD, BCOP Clinical Pharmacy Specialist Memorial Sloan Kettering Cancer Center New York, New York Gregory J. Riely, MD, PhD Attending Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Carly Rosemore, MD Fellow, Pediatric Hematology/ Oncology Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Barry S. Rosenstein, PhD Professor of Radiation Oncology and Genetics & Genomic Science Icahn School of Medicine at Mount Sinai Course Director, Radiation and Cancer Biology Memorial Sloan Kettering Cancer Center New York, New York Jaclyn Rosenzweig, MD Fellow, Pediatric Hematology/ Oncology Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Sameer Farouk Sait, MBBS Instructor Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Reggie T. Saldivar, MD Associate Program Director, Hospice and Palliative Medicine Fellowship Assistant Attending Memorial Sloan Kettering Cancer Center New York, New York

Gilles Salles, MD, PhD Chief, Lymphoma Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Ernesto Santos, MD Attending Physician Interventional Radiology Service, Department of Radiology Memorial Sloan Kettering Cancer Center New York, New York Patricia Mae G. Santos, MD, MS Resident Physician Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York Howard I. Scher, MD D.Wayne Calloway Chair in Urologic Oncology Head, Biomarker Development Program Office of the Physician in Chief Member and Attending Physician Genitourinary Oncology Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Adam J. Schoenfeld, MD Assistant Attending Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Joshua D. Schoenfeld, MD, PhD

Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Ramy Sedhom, MD Fellow, Hospice and Palliative Medicine Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Neil H. Segal, MD, PhD Associate Attending Gastrointestinal Oncology Service, Department of Medicine New York, New York Varun Shah, MD Fellow Interventional Pulmonology— Pulmonary Medicine Memorial Sloan Kettering Cancer Center New York, New York Sanam Shahid, MD Fellow, Pediatric Hematology/ Oncology Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Armin Shahrokni, MD, MPH Associate Attending Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Anupriya Singhal, MD, PhD Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Emily Slotkin, MD Assistant Attending, Pediatric Sarcoma Service Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Melody Smith, MD, MS Assistant Attending Adult Blood & Marrow Stem Cell Transplantation Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York

James W. Smithy, MD, MHS Fellow, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Krisoula H. Spatz, PharmD Clinical Pharmacy Specialist Department of Pediatric Oncology Memorial Sloan Kettering Cancer Center New York, New York Barbara Spitzer, MD Assistant Attending, Transplantation and Cellular Therapy Service Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Robert Stanley, MD, PhD Fellow, Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Jessica Stiefel, MD, MS Assistant Attending Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Aaron James Stonestrom, MD, PhD Fellow, Hematology & Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Maria Luisa Sulis, MD Member,Attending physician Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York

SAMPLE

Anna M. Varghese, MD Assistant Attending Department of Medicine

Neil K. Taunk, MD, MSCTS Assistant Professor Radiation Oncology University of Pennsylvania Philadelphia, Pennsylvania William P. Tew, MD Attending Clinical Director Gynecologic Oncology Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Meghan C. Thompson, MD Fellow, Hematology & Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Katherine Thornton, MD Associate Attending, Medical Oncology Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Tiffany A. Traina, MD Vice Chair, Oncology Care Breast Medicine Service, Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Alexandre G. Troullioud Lucas, MD, MSc Fellow, Pediatric Hematology/ Oncology Department of Pediatrics Memorial Sloan Kettering Cancer Center New York, New York Grashma Vadakkel, PharmD, BCOP Bone Marrow Transplant Clinical Pharmacy Specialist Bone Marrow Transplant Memorial Sloan Kettering Cancer Center New York, New York

Division of Solid Tumor Oncology, Gastrointestinal Oncology Service Memorial Sloan Kettering Cancer Center New York, New York Maya Viavant, MD Chief Resident Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Andrew Vickers, PhD Attending Research Methodologist Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York, New York Martin H. Voss, MD Clinical Director, Genitourinary Oncology Service Department of Medicine Memorial Sloan Kettering Cancer Center New York, New York Alice Chia-chi Wei, MD, MSc, FRCSC, FACS Associate Attending Surgeon Department of Surgery Memorial Sloan Kettering Cancer Center New York, New York

Taylor M. Weis, PharmD Clinical Pharmacist Specialist— Leukemia Department of Pharmacy Memorial Sloan Kettering Cancer Center New York, New York N. Ari Wijetunga, MD, PhD, MS Resident Department of Radiation Oncology Memorial Sloan Kettering Cancer Center New York, New York Copyright © 2023 Wolters Kluwer, Inc. Unauthorized reproduction of the content is prohibited. SAMPLE

Page 2 Page 3 Page 4 Page 5 Page 6 Page 7 Page 8 Page 9 Page 10 Page 11 Page 12 Page 13 Page 14 Page 15 Page 16 Page 17 Page 18 Page 19 Page 20 Page 21 Page 22 Page 23 Page 24 Page 25 Page 26 Page 27 Page 28 Page 29 Page 30 Page 31 Page 32 Page 33 Page 34 Page 35 Page 36 Page 37 Page 38 Page 39 Page 40 Page 41 Page 42 Page 43

Made with FlippingBook - Share PDF online