8-A837A-2017-Books-00129-029-060_Katz_Sec1_Ch02-ROUND-1

S E C T I O N I | T H Y R O I D

50

TT 1 bpCCND 65 1.7 3.1 10.7 0 100% 26.2% of patients lymph nodes. P-value NS NS NS TT 478 1 67.4 1.5 2.3 1.5 44 11 had positive

TT 1 ibpCCND 102 1.5 80.2 3.9 11.8 5.9 56 67.2% of patients lymph nodes. P-value 0.001 NS 0.001 0.02 Raffaelli et al, 163 2008–2010 TT 62 1.2 25.5 0 0 0 NR 11 had positive

TT 1 ipCCND 62 1.2 8.5 1 0 1 42% of patients had positive TT 1 bpCCND 62 1.4 25 0 1 0

lymph nodes.

Patients with high risk

received RAI therapy.

Grade of

Evidence and Comments

2.1 4.5 0 88% 11

P-value NS NS NS RLN, recurrent laryngeal nerve; RAI, radioactive iodine; TT, total thyroidectomy; CCND, central compartment neck dissection; bpCCND, bilateral prophylactic CCND; ibpCCND, ipsilateral bilateral prophylactic CCND; ipCCND, ipsilateral prophylactic CCND; NR, not recorded; NS, not significant; DFS, disease-free survival; ETE, extrathyroidal extension; ipsi, ipsilateral; RFS, relapse-free survival; LCR, local control rate. Grades: 11 low; 111 moderate. *Median. † The overall rate of reoperations was not significantly different, but the central compartment reoperation rate was higher with TT (6.5% vs. 1.5%: P-value 5 0.004).

Permanent (%) RAI Use

RLN,

Hypoparathyroidism, Permanent (%)

Recurrence Rate (%)

Follow-up (mo)

100 mo

Mean

TT 220 1.6* Overall,

Tumor Size (cm)

Mean

Author, Years of Trial Procedure TABLE 2-1 Selected Retrospective Studies Comparing Total Thyroidectomy with or without Prophylactic Central Compartment Neck Dissection (continued) No. of Patients Calo et al, 160 2002–2010 Ywata de Carvalho et al, 164 1996–2007