7-A200D-2017-Books-00020-FamilyMedicine_Essentials_MECH-FLIP-FINAL

Quick-Reference Pocket Guides

Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine, 6 th Edition Marc S. Sabatine, MD

THYROID DISORDERS

Diagnostic Studies inThyroid Disorders

Test

Comments

Most sensitive test to detect 1 ° hypo- and hyperthyroidism May be inappropriately normal in central etiologies ↓ ’d by dopamine,glucocorticoids,severe illness

Thyroid-stimulating hormone (TSH)

FreeT 4 TotalT 3

( FT 4

)

UnboundT 4

,not influenced byTBG

Total serum concentrations ( ∴ influenced byTBG)

andT 4

↑ TBG ( ∴ ↑ T 4 hereditary ↓ TBG ( ∴ ↓ T 4

Thyroxine-binding globulin (TBG)

):estrogen (OCP,pregnancy),hepatitis,opioids,

Key clinical information and solutions to common problems in internal medicine right at your fingertips. Prepared by residents and attending physicians at Massachusetts General Hospital, this portable, best-selling reference tackles the diagnosis and treatment of the most common disorders in cardiology, pulmonary medicine, gastroenterology, nephrology, hematology- oncology, infectious diseases, endocrinology, rheumatology, and neurology. d d Tables, algorithms, and bulleted lists focus on the information you need to make an accurate diagnosis and develop a treatment plan d d Updates in every chapter keep you current with what’s new in internal medicine d d The six-ring, loose-leaf binder allows you to add your own notes d d A 16-page color insert with classic, normal, and abnormal radiographs, CT scans, echocardiograms, peripheral blood smears, and urinalyses commonly seen in practice d d User-friendly tabs and a 2-color design help you find information quickly d d References to landmark papers help you answer questions from attendings and residents—all from a trusted source acceptable for use on rounds d d Surgical, OB-GYN, and ophthalmic consult sections guide you to ask the right questions and get the best care for your patients

):androgens,glucocorticoids,nephritic syndrome,cirrhosis,acromegaly,antiepileptics,hereditary

ReverseT 3

Inactive, ↑ ’d in sick euthyroid syndrome

Thyroid antibodies

Antithyroid peroxidase (TPO) seen in Hashimoto’s (high titer), painless thyroiditis and Graves’ disease (low titer) Thyroid-stimulating Ig (TSI) and thyrotropin-binding inhibitory immunoglobulin (TBII) seen in Graves’ disease

Thyroglobulin

↑ ’d in goiter,hyperthyroidism and thyroiditis ↓ ’d in factitious ingestion of thyroid hormone Tumor marker for thyroid cancer only after total thyroidectomy and radioiodine therapy

Radioactive iodine uptake ( RAIU ) scan

Useful to differentiate causes of hyperthyroidism ä uptake homogeneous = Graves’ disease heterogeneous = multinodular goiter 1 focus of uptake w/ suppression of rest of gland = hot nodule no uptake = subacute painful (de Quervain’s) or silent thyroiditis,exogenous thyroid hormone,recent iodine load, struma ovarii or antithyroid drugs

t hyroid 7-3

( Lancet 200 1 ;357:6 1 9 & Thyroid 2003; 1 3: 1 9) Figure 7- 1 Approachtothyroiddisorders

TSH

decreased

normal

increased

FreeT 4

FreeT 4

? secondary (central)disease

decreased

increased

normal

normal

Central Hypothyroidism

TSH-secreting adenoma (centralhyper- thyroidism) or Thyroid hormone resistance

increased

decreased

Subclinical hyperthyroidism

Subclinical hypo- thyroidism

Primary hyperthyroidism

Primary hypothyroidism

RAIU

diffuse

focal

none

serum thyroglobulin

homogeneous

heterogeneous

↓

↑

Graves’ disease

Toxic multinodular goiter

Functioning adenoma

Thyrotoxicosis factitia

Thyroiditis Iodine load, or Strumaovarii

H ypotHyroidiSm

Etiologies • Primary ( > 90% of cases of hypothyroidism; ↓ freeT 4 , ↑ TSH) Goitrous: Hashimoto’s thyroiditis (after hyperthyroid phase of thyroiditis),iodine deficiency,lithium,amiodarone

LWBK1568-C07_p01-16.indd 3

31/08/16 3:23 PM

“Best handbook for internal medicine residents and medical students. Concise, evidence-based, and quick review for day-to-day clinical cases.” 5-Star Amazon Review

280 pages $64.99 ISBN: 9781496349484

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